FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783111469> ?p ?o ?g. }

• W2783111469 abstract "Binding of extracellular netrin-1 to its receptors, deleted in colorectal cancer (DCC) and uncoordinated gene 5H2 (UNC5H2), inhibits apoptosis mediated by these receptors. A neuron-specific kinesin motor protein, KIF1A, has been shown to participate in netrin-1 secretion. This study aimed to identify the roles of netrin-1 and KIF1A in secondary brain injury after intracerebral hemorrhage (ICH) and the potential mechanisms. An autologous blood ICH model was established in adult male Sprague-Dawley rats, and cultured neurons were exposed to OxyHb to mimic ICH conditions in vitro. Mouse recombinant netrin-1, expression vectors encoding KIF1A, and KIF1A-specific siRNAs were administered intracerebroventricularly. After ICH, protein levels of netrin-1, DCC, and UNC5H2 increased, while protein levels of KIF1A decreased. Levels of UNC5H2 and DCC bound to netrin-1 increased after ICH but were significantly lower than the increase in total amount of protein. Administration of recombinant netrin-1 attenuated neuronal apoptosis and degeneration in ICH rats. Moreover, KIF1A overexpression increased concentrations of netrin-1 in cerebrospinal fluid and cell culture supernatant and exerted neuroprotective effects via netrin-1 and its receptor pathways. KIF1A plays a critical role in netrin-1 secretion by neurons. An increase in protein levels of netrin-1 may be a neuroprotective strategy after ICH. However, this process is almost completely abolished by ICH-induced loss of KIF1A. An exogenous increase of KIF1A may be a potential strategy for neuroprotection via the netrin-1 pathway." @default.
• W2783111469 created "2018-01-26" @default.
• W2783111469 creator A5004356555 @default.
• W2783111469 creator A5024334879 @default.
• W2783111469 creator A5039441451 @default.
• W2783111469 creator A5041993686 @default.
• W2783111469 creator A5042241049 @default.
• W2783111469 creator A5045067652 @default.
• W2783111469 creator A5056354165 @default.
• W2783111469 creator A5072961920 @default.
• W2783111469 creator A5079524437 @default.
• W2783111469 date "2018-01-11" @default.
• W2783111469 modified "2023-10-17" @default.
• W2783111469 title "Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats" @default.
• W2783111469 cites W1678034977 @default.
• W2783111469 cites W1871814825 @default.
• W2783111469 cites W1956809569 @default.
• W2783111469 cites W1963680784 @default.
• W2783111469 cites W1969611102 @default.
• W2783111469 cites W1991328725 @default.
• W2783111469 cites W1998347477 @default.
• W2783111469 cites W2016490383 @default.
• W2783111469 cites W2026960985 @default.
• W2783111469 cites W2029120000 @default.
• W2783111469 cites W2031939491 @default.
• W2783111469 cites W2033480316 @default.
• W2783111469 cites W2039344041 @default.
• W2783111469 cites W2040170133 @default.
• W2783111469 cites W2041890434 @default.
• W2783111469 cites W2047250323 @default.
• W2783111469 cites W2052309340 @default.
• W2783111469 cites W2073231646 @default.
• W2783111469 cites W2075086498 @default.
• W2783111469 cites W2083224632 @default.
• W2783111469 cites W2090295813 @default.
• W2783111469 cites W2091443953 @default.
• W2783111469 cites W2094550544 @default.
• W2783111469 cites W2098751075 @default.
• W2783111469 cites W2116094159 @default.
• W2783111469 cites W2122564431 @default.
• W2783111469 cites W2124684134 @default.
• W2783111469 cites W2142296555 @default.
• W2783111469 cites W2143116221 @default.
• W2783111469 cites W2154616416 @default.
• W2783111469 cites W2156589326 @default.
• W2783111469 cites W2167046611 @default.
• W2783111469 cites W2294227584 @default.
• W2783111469 cites W2383640966 @default.
• W2783111469 cites W2410078767 @default.
• W2783111469 cites W2417171888 @default.
• W2783111469 cites W2422150945 @default.
• W2783111469 cites W2462707751 @default.
• W2783111469 cites W2498679051 @default.
• W2783111469 cites W2515899158 @default.
• W2783111469 cites W2518059955 @default.
• W2783111469 cites W2520327637 @default.
• W2783111469 cites W2524492724 @default.
• W2783111469 cites W2551548729 @default.
• W2783111469 cites W2552912919 @default.
• W2783111469 cites W2555819662 @default.
• W2783111469 cites W2599437710 @default.
• W2783111469 cites W2607283788 @default.
• W2783111469 cites W2615735913 @default.
• W2783111469 cites W2619122250 @default.
• W2783111469 doi "https://doi.org/10.3389/fncel.2017.00432" @default.
• W2783111469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768630" @default.
• W2783111469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375318" @default.
• W2783111469 hasPublicationYear "2018" @default.
• W2783111469 type Work @default.
• W2783111469 sameAs 2783111469 @default.
• W2783111469 citedByCount "14" @default.
• W2783111469 countsByYear W27831114692018 @default.
• W2783111469 countsByYear W27831114692019 @default.
• W2783111469 countsByYear W27831114692020 @default.
• W2783111469 countsByYear W27831114692021 @default.
• W2783111469 countsByYear W27831114692022 @default.
• W2783111469 crossrefType "journal-article" @default.
• W2783111469 hasAuthorship W2783111469A5004356555 @default.
• W2783111469 hasAuthorship W2783111469A5024334879 @default.
• W2783111469 hasAuthorship W2783111469A5039441451 @default.
• W2783111469 hasAuthorship W2783111469A5041993686 @default.
• W2783111469 hasAuthorship W2783111469A5042241049 @default.
• W2783111469 hasAuthorship W2783111469A5045067652 @default.
• W2783111469 hasAuthorship W2783111469A5056354165 @default.
• W2783111469 hasAuthorship W2783111469A5072961920 @default.
• W2783111469 hasAuthorship W2783111469A5079524437 @default.
• W2783111469 hasBestOaLocation W27831114691 @default.
• W2783111469 hasConcept C126322002 @default.
• W2783111469 hasConcept C127955056 @default.
• W2783111469 hasConcept C170493617 @default.
• W2783111469 hasConcept C185592680 @default.
• W2783111469 hasConcept C25498285 @default.
• W2783111469 hasConcept C2777094939 @default.
• W2783111469 hasConcept C2777736543 @default.
• W2783111469 hasConcept C69125201 @default.
• W2783111469 hasConcept C71924100 @default.
• W2783111469 hasConcept C86803240 @default.
• W2783111469 hasConcept C95444343 @default.
• W2783111469 hasConcept C98274493 @default.
• W2783111469 hasConceptScore W2783111469C126322002 @default.

• next