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- W2783111562 abstract "Ginsenosides are the principal bioactive ingredients of Panax ginseng and possess diverse notable pharmacological activities. UDP-glycosyltransferase (UGT)-mediated glycosylation of the C6–OH and C20–OH of protopanaxatriol (PPT) is the prominent biological modification that contributes to the immense structural and functional diversity of PPT-type ginsenosides. In this study, the glycosylation of PPT and PPT-type ginsenosides was achieved using a promiscuous glycosyltransferase (Bs-YjiC) from Bacillus subtilis 168. PPT was selected as the probe for the in vitro glycodiversification of PPT-type ginsenosides using diverse UDP-sugars as sugar donors. Structural analysis of the newly biosynthesized products demonstrated that Bs-YjiC can transfer a glucosyl moiety to the free C3–OH, C6–OH, and C12–OH of PPT. Five PPT-type ginsenosides were biosynthesized, including ginsenoside Rh1 and four unnatural ginsenosides. The present study suggests flexible microbial UGTs play an important role in the enzymatic synthesis of novel ginsenosides." @default.
- W2783111562 created "2018-01-26" @default.
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- W2783111562 date "2018-01-22" @default.
- W2783111562 modified "2023-10-18" @default.
- W2783111562 title "Use of a Promiscuous Glycosyltransferase from <i>Bacillus subtilis</i> 168 for the Enzymatic Synthesis of Novel Protopanaxatriol-Type Ginsenosides" @default.
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- W2783111562 doi "https://doi.org/10.1021/acs.jafc.7b03907" @default.
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