Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783111617> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2783111617 endingPage "36" @default.
- W2783111617 startingPage "30" @default.
- W2783111617 abstract "Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the Aspergillus fumigatus is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by the target of rapamycin (Tor) kinase. Autophagy is highly regulated and is under the control of a number of signaling pathways, including the Tor pathway, which coordinates cell growth with nutrient availability. The data shows that autophagy in A.fumigatus is also controlled by the cAMP-dependent protein kinase (PKA) pathway. Elevated levels of PKA activity inhibited autophagy and inactivation of the PKA pathway is sufficient to induce a robust autophagy response. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only two putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. Here we will discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development." @default.
- W2783111617 created "2018-01-26" @default.
- W2783111617 creator A5018129467 @default.
- W2783111617 creator A5021291688 @default.
- W2783111617 creator A5039923487 @default.
- W2783111617 creator A5052152292 @default.
- W2783111617 date "2017-01-01" @default.
- W2783111617 modified "2023-09-27" @default.
- W2783111617 title "PKA-mediated Autophagy in Aspergillus fumigates" @default.
- W2783111617 doi "https://doi.org/10.18483/ijsci.1488" @default.
- W2783111617 hasPublicationYear "2017" @default.
- W2783111617 type Work @default.
- W2783111617 sameAs 2783111617 @default.
- W2783111617 citedByCount "1" @default.
- W2783111617 countsByYear W27831116172022 @default.
- W2783111617 crossrefType "journal-article" @default.
- W2783111617 hasAuthorship W2783111617A5018129467 @default.
- W2783111617 hasAuthorship W2783111617A5021291688 @default.
- W2783111617 hasAuthorship W2783111617A5039923487 @default.
- W2783111617 hasAuthorship W2783111617A5052152292 @default.
- W2783111617 hasBestOaLocation W27831116171 @default.
- W2783111617 hasConcept C171896709 @default.
- W2783111617 hasConcept C184235292 @default.
- W2783111617 hasConcept C190283241 @default.
- W2783111617 hasConcept C203522944 @default.
- W2783111617 hasConcept C2776030549 @default.
- W2783111617 hasConcept C2779787849 @default.
- W2783111617 hasConcept C2780042272 @default.
- W2783111617 hasConcept C2909523446 @default.
- W2783111617 hasConcept C31573885 @default.
- W2783111617 hasConcept C55493867 @default.
- W2783111617 hasConcept C62478195 @default.
- W2783111617 hasConcept C86803240 @default.
- W2783111617 hasConcept C87325107 @default.
- W2783111617 hasConcept C89423630 @default.
- W2783111617 hasConcept C95444343 @default.
- W2783111617 hasConcept C97029542 @default.
- W2783111617 hasConceptScore W2783111617C171896709 @default.
- W2783111617 hasConceptScore W2783111617C184235292 @default.
- W2783111617 hasConceptScore W2783111617C190283241 @default.
- W2783111617 hasConceptScore W2783111617C203522944 @default.
- W2783111617 hasConceptScore W2783111617C2776030549 @default.
- W2783111617 hasConceptScore W2783111617C2779787849 @default.
- W2783111617 hasConceptScore W2783111617C2780042272 @default.
- W2783111617 hasConceptScore W2783111617C2909523446 @default.
- W2783111617 hasConceptScore W2783111617C31573885 @default.
- W2783111617 hasConceptScore W2783111617C55493867 @default.
- W2783111617 hasConceptScore W2783111617C62478195 @default.
- W2783111617 hasConceptScore W2783111617C86803240 @default.
- W2783111617 hasConceptScore W2783111617C87325107 @default.
- W2783111617 hasConceptScore W2783111617C89423630 @default.
- W2783111617 hasConceptScore W2783111617C95444343 @default.
- W2783111617 hasConceptScore W2783111617C97029542 @default.
- W2783111617 hasIssue "12" @default.
- W2783111617 hasLocation W27831116171 @default.
- W2783111617 hasLocation W27831116172 @default.
- W2783111617 hasOpenAccess W2783111617 @default.
- W2783111617 hasPrimaryLocation W27831116171 @default.
- W2783111617 hasRelatedWork W1978998067 @default.
- W2783111617 hasRelatedWork W1985158738 @default.
- W2783111617 hasRelatedWork W2083919459 @default.
- W2783111617 hasRelatedWork W2103669547 @default.
- W2783111617 hasRelatedWork W2108298020 @default.
- W2783111617 hasRelatedWork W2136454190 @default.
- W2783111617 hasRelatedWork W2164998112 @default.
- W2783111617 hasRelatedWork W2898102997 @default.
- W2783111617 hasRelatedWork W2990912547 @default.
- W2783111617 hasRelatedWork W773396943 @default.
- W2783111617 hasVolume "3" @default.
- W2783111617 isParatext "false" @default.
- W2783111617 isRetracted "false" @default.
- W2783111617 magId "2783111617" @default.
- W2783111617 workType "article" @default.