FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783115824> ?p ?o ?g. }

• W2783115824 abstract "Huntington's and Parkinson's Diseases (HD and PD) are neurodegenerative disorders that share some pathological features but are disparate in others. For example, while both diseases are marked by aberrant protein aggregation in the brain, the specific proteins that aggregate and types of neurons affected differ. A better understanding of the molecular similarities and differences between these two diseases may lead to a more complete mechanistic picture of both the individual diseases and the neurodegenerative process in general. We sought to characterize the common transcriptional signature of HD and PD as well as genes uniquely implicated in each of these diseases using mRNA-Seq data from post mortem human brains in comparison to neuropathologically normal controls. The enriched biological pathways implicated by HD differentially expressed genes show remarkable consistency with those for PD differentially expressed genes and implicate the common biological processes of neuroinflammation, apoptosis, transcriptional dysregulation, and neuron-associated functions. Comparison of the differentially expressed (DE) genes highlights a set of consistently altered genes that span both diseases. In particular, processes involving nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and transcription factor cAMP response element-binding protein (CREB) are the most prominent among the genes common to HD and PD. When the combined HD and PD data are compared to controls, relatively few additional biological processes emerge as significantly enriched, suggesting that most pathways are independently seen within each disorder. Despite showing comparable numbers of DE genes, DE genes unique to HD are enriched in far more coherent biological processes than the DE genes unique to PD, suggesting that PD may represent a more heterogeneous disorder. The complexity of the biological processes implicated by this analysis provides impetus for the development of better experimental models to validate the results." @default.
• W2783115824 created "2018-01-26" @default.
• W2783115824 creator A5036456839 @default.
• W2783115824 creator A5041586675 @default.
• W2783115824 creator A5069179862 @default.
• W2783115824 date "2018-01-11" @default.
• W2783115824 modified "2023-10-14" @default.
• W2783115824 title "Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles" @default.
• W2783115824 cites W104566287 @default.
• W2783115824 cites W1480927111 @default.
• W2783115824 cites W1527831788 @default.
• W2783115824 cites W1544061551 @default.
• W2783115824 cites W1545847477 @default.
• W2783115824 cites W1965114915 @default.
• W2783115824 cites W1969999276 @default.
• W2783115824 cites W1973284786 @default.
• W2783115824 cites W1975747878 @default.
• W2783115824 cites W1977252372 @default.
• W2783115824 cites W1986288479 @default.
• W2783115824 cites W1990921901 @default.
• W2783115824 cites W2000059653 @default.
• W2783115824 cites W2002707258 @default.
• W2783115824 cites W2003551942 @default.
• W2783115824 cites W2010484888 @default.
• W2783115824 cites W2013416277 @default.
• W2783115824 cites W2023265142 @default.
• W2783115824 cites W2024064411 @default.
• W2783115824 cites W2030575711 @default.
• W2783115824 cites W2030592839 @default.
• W2783115824 cites W2040892689 @default.
• W2783115824 cites W2045023032 @default.
• W2783115824 cites W2047206799 @default.
• W2783115824 cites W2048463976 @default.
• W2783115824 cites W2048897966 @default.
• W2783115824 cites W2054109317 @default.
• W2783115824 cites W2055936471 @default.
• W2783115824 cites W2058006779 @default.
• W2783115824 cites W2073449985 @default.
• W2783115824 cites W2075800746 @default.
• W2783115824 cites W2077793109 @default.
• W2783115824 cites W2078129874 @default.
• W2783115824 cites W2079124378 @default.
• W2783115824 cites W2080683775 @default.
• W2783115824 cites W2080995987 @default.
• W2783115824 cites W2086896644 @default.
• W2783115824 cites W2087581370 @default.
• W2783115824 cites W2090539879 @default.
• W2783115824 cites W2093932385 @default.
• W2783115824 cites W2096193724 @default.
• W2783115824 cites W2096465161 @default.
• W2783115824 cites W2099281994 @default.
• W2783115824 cites W2101764987 @default.
• W2783115824 cites W2102648007 @default.
• W2783115824 cites W2106206610 @default.
• W2783115824 cites W2113768712 @default.
• W2783115824 cites W2114104545 @default.
• W2783115824 cites W2114144036 @default.
• W2783115824 cites W2118017277 @default.
• W2783115824 cites W2124176874 @default.
• W2783115824 cites W2127558621 @default.
• W2783115824 cites W2130410032 @default.
• W2783115824 cites W2133775329 @default.
• W2783115824 cites W2134526812 @default.
• W2783115824 cites W2134862369 @default.
• W2783115824 cites W2139239806 @default.
• W2783115824 cites W2140099276 @default.
• W2783115824 cites W2140795771 @default.
• W2783115824 cites W2143656230 @default.
• W2783115824 cites W2146511318 @default.
• W2783115824 cites W2147983580 @default.
• W2783115824 cites W2151003482 @default.
• W2783115824 cites W2153899872 @default.
• W2783115824 cites W2156564520 @default.
• W2783115824 cites W2161794681 @default.
• W2783115824 cites W2164049923 @default.
• W2783115824 cites W2169456326 @default.
• W2783115824 cites W2179438025 @default.
• W2783115824 cites W2183321684 @default.
• W2783115824 cites W2195645799 @default.
• W2783115824 cites W2334516132 @default.
• W2783115824 cites W2586465357 @default.
• W2783115824 cites W2952535963 @default.
• W2783115824 cites W303152743 @default.
• W2783115824 cites W904184522 @default.
• W2783115824 doi "https://doi.org/10.3389/fnmol.2017.00430" @default.
• W2783115824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768647" @default.
• W2783115824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375298" @default.
• W2783115824 hasPublicationYear "2018" @default.
• W2783115824 type Work @default.
• W2783115824 sameAs 2783115824 @default.
• W2783115824 citedByCount "26" @default.
• W2783115824 countsByYear W27831158242019 @default.
• W2783115824 countsByYear W27831158242020 @default.
• W2783115824 countsByYear W27831158242021 @default.
• W2783115824 countsByYear W27831158242022 @default.
• W2783115824 countsByYear W27831158242023 @default.
• W2783115824 crossrefType "journal-article" @default.
• W2783115824 hasAuthorship W2783115824A5036456839 @default.
• W2783115824 hasAuthorship W2783115824A5041586675 @default.
• W2783115824 hasAuthorship W2783115824A5069179862 @default.

• next