FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783116043> ?p ?o ?g. }

• W2783116043 abstract "Prostate cancer (PCa) is the second most common type of cancer and the 6th leading cause of cancer‑associated mortality worldwide. Accumulated evidence suggests that PCa initiation and progression are controlled by microRNAs (miRNAs). Therefore, investigating PCa‑associated miRNAs may provide novel biomarkers for the diagnosis and treatment of patients with PCa. In the present study it was demonstrated that miRNA‑136 (miR‑136) expression was significantly downregulated in PCa tissues and cell lines. The resumption of miR‑136 expression suppressed cell proliferation and invasion in PCa cells. Bioinformatics analysis predicted that mitogen‑activated protein kinase kinase 4 (MAP2K4) was a direct target of miR‑136. This prediction was experimentally confirmed by a luciferase reporter assay, RT‑qPCR and western blot analysis. MAP2K4 was highly expressed in PCa tissues and inversely correlated with the miR‑136 expression level. Additionally, the restoration of MAP2K4 expression significantly blocked the inhibitory effects of miR‑136 on cell proliferation and invasion in PCa cells. Therefore, miR‑136 may suppress the proliferation and invasion of PCa cells by targeting MAP2K4 and may be a novel candidate target for cancer therapy against PCa." @default.
• W2783116043 created "2018-01-26" @default.
• W2783116043 creator A5001743192 @default.
• W2783116043 creator A5017007472 @default.
• W2783116043 creator A5064607240 @default.
• W2783116043 creator A5066094762 @default.
• W2783116043 creator A5090561112 @default.
• W2783116043 date "2018-01-10" @default.
• W2783116043 modified "2023-09-29" @default.
• W2783116043 title "MicroRNA‑136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen‑activated protein kinase kinase 4" @default.
• W2783116043 cites W1987691057 @default.
• W2783116043 cites W1988303298 @default.
• W2783116043 cites W2002995168 @default.
• W2783116043 cites W2004174653 @default.
• W2783116043 cites W2011963361 @default.
• W2783116043 cites W2015774542 @default.
• W2783116043 cites W2027424913 @default.
• W2783116043 cites W2037361029 @default.
• W2783116043 cites W2039340234 @default.
• W2783116043 cites W2042011375 @default.
• W2783116043 cites W2048556644 @default.
• W2783116043 cites W2053525092 @default.
• W2783116043 cites W2059357290 @default.
• W2783116043 cites W2076335256 @default.
• W2783116043 cites W2099790717 @default.
• W2783116043 cites W2106168045 @default.
• W2783116043 cites W2106787323 @default.
• W2783116043 cites W2107277218 @default.
• W2783116043 cites W2154197027 @default.
• W2783116043 cites W2155549021 @default.
• W2783116043 cites W2162674813 @default.
• W2783116043 cites W2170552969 @default.
• W2783116043 cites W2272984102 @default.
• W2783116043 cites W2315534294 @default.
• W2783116043 cites W2344661420 @default.
• W2783116043 cites W2347100538 @default.
• W2783116043 cites W2354791204 @default.
• W2783116043 cites W2517684962 @default.
• W2783116043 cites W2550089865 @default.
• W2783116043 cites W2551377220 @default.
• W2783116043 cites W2559837425 @default.
• W2783116043 cites W2597865621 @default.
• W2783116043 cites W2730102792 @default.
• W2783116043 cites W2736042000 @default.
• W2783116043 cites W2737983424 @default.
• W2783116043 cites W2753935426 @default.
• W2783116043 doi "https://doi.org/10.3892/mmr.2018.8417" @default.
• W2783116043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29328468" @default.
• W2783116043 hasPublicationYear "2018" @default.
• W2783116043 type Work @default.
• W2783116043 sameAs 2783116043 @default.
• W2783116043 citedByCount "10" @default.
• W2783116043 countsByYear W27831160432018 @default.
• W2783116043 countsByYear W27831160432019 @default.
• W2783116043 countsByYear W27831160432020 @default.
• W2783116043 countsByYear W27831160432021 @default.
• W2783116043 countsByYear W27831160432022 @default.
• W2783116043 countsByYear W27831160432023 @default.
• W2783116043 crossrefType "journal-article" @default.
• W2783116043 hasAuthorship W2783116043A5001743192 @default.
• W2783116043 hasAuthorship W2783116043A5017007472 @default.
• W2783116043 hasAuthorship W2783116043A5064607240 @default.
• W2783116043 hasAuthorship W2783116043A5066094762 @default.
• W2783116043 hasAuthorship W2783116043A5090561112 @default.
• W2783116043 hasBestOaLocation W27831160431 @default.
• W2783116043 hasConcept C104317684 @default.
• W2783116043 hasConcept C121608353 @default.
• W2783116043 hasConcept C145059251 @default.
• W2783116043 hasConcept C1491633281 @default.
• W2783116043 hasConcept C184235292 @default.
• W2783116043 hasConcept C2780192828 @default.
• W2783116043 hasConcept C2781018059 @default.
• W2783116043 hasConcept C29537977 @default.
• W2783116043 hasConcept C502942594 @default.
• W2783116043 hasConcept C54355233 @default.
• W2783116043 hasConcept C62112901 @default.
• W2783116043 hasConcept C86803240 @default.
• W2783116043 hasConcept C95444343 @default.
• W2783116043 hasConcept C97029542 @default.
• W2783116043 hasConceptScore W2783116043C104317684 @default.
• W2783116043 hasConceptScore W2783116043C121608353 @default.
• W2783116043 hasConceptScore W2783116043C145059251 @default.
• W2783116043 hasConceptScore W2783116043C1491633281 @default.
• W2783116043 hasConceptScore W2783116043C184235292 @default.
• W2783116043 hasConceptScore W2783116043C2780192828 @default.
• W2783116043 hasConceptScore W2783116043C2781018059 @default.
• W2783116043 hasConceptScore W2783116043C29537977 @default.
• W2783116043 hasConceptScore W2783116043C502942594 @default.
• W2783116043 hasConceptScore W2783116043C54355233 @default.
• W2783116043 hasConceptScore W2783116043C62112901 @default.
• W2783116043 hasConceptScore W2783116043C86803240 @default.
• W2783116043 hasConceptScore W2783116043C95444343 @default.
• W2783116043 hasConceptScore W2783116043C97029542 @default.
• W2783116043 hasLocation W27831160431 @default.
• W2783116043 hasLocation W27831160432 @default.
• W2783116043 hasOpenAccess W2783116043 @default.
• W2783116043 hasPrimaryLocation W27831160431 @default.
• W2783116043 hasRelatedWork W2013549141 @default.
• W2783116043 hasRelatedWork W2535807463 @default.
• W2783116043 hasRelatedWork W2791346339 @default.

• next