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- W2783116119 abstract "Summary Aims Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle‐associated protein 1 ( NUSAP 1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP 1 in gliomas remains unclear. Methods NUSAP 1 expression in gliomas with different grades was investigated based on GEO glioma datasets. Kaplan‐Meier survival analysis was used to evaluate its prognostic significance. In vitro assays were also performed to evaluate effects of NUSAP 1 on malignant phenotypes of glioma cells by silencing NUSAP 1. Results NUSAP 1 expression was correlated not only with glioma grade but also with prognosis of glioma patients. NUSAP 1 depletion suppressed proliferation of U251 cells by inducing cell cycle arrest at G2/M phase and apoptosis. NUSAP 1 depletion rendered U251 cells impaired migratory ability as well. Conclusion NUSAP 1 is a potential prognosis marker for glioma patients and therapeutic strategies targeting NUSAP 1 might hold promise in improving glioma treatment." @default.
- W2783116119 created "2018-01-26" @default.
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- W2783116119 date "2018-01-15" @default.
- W2783116119 modified "2023-10-18" @default.
- W2783116119 title "Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients" @default.
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- W2783116119 doi "https://doi.org/10.1111/cns.12803" @default.
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