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• W2783117803 abstract "Scope Xanthohumol (XN), a prenylated flavonoid found in hops, exhibits anti‐inflammatory and antioxidant properties. However, poor bioavailability may limit therapeutic applications. As food components are known to modulate polyphenol absorption, the objective is to determine whether a protein matrix could enhance the bioavailability of XN post oral consumption in humans. Methods and results This is a randomized, double‐blind, crossover study in healthy participants ( n = 6) evaluating XN and its major metabolites (isoxanthohumol [IX], 6‐ and 8‐prenylnaringenin [6‐PN, 8‐PN]) for 6 h following consumption of 12.4 mg of XN delivered via a spent hops‐rice protein matrix preparation or a control spent hops preparation. Plasma XN and metabolites are measured by LC–MS/MS. C max , T max , and area‐under‐the‐curve (AUC) values were determined. Circulating XN and metabolite response to each treatment was not bioequivalent. Plasma concentrations of XN and XN + metabolites (AUC) are greater with consumption of the spent hops‐rice protein matrix preparation. Conclusion Compared to a standard spent hops powder, a protein‐rich spent hops matrix demonstrates enhanced plasma levels of XN and metabolites following acute oral intake." @default.
• W2783117803 created "2018-01-26" @default.
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• W2783117803 date "2018-02-26" @default.
• W2783117803 modified "2023-10-01" @default.
• W2783117803 title "Rice Protein Matrix Enhances Circulating Levels of Xanthohumol Following Acute Oral Intake of Spent Hops in Humans" @default.
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• W2783117803 doi "https://doi.org/10.1002/mnfr.201700692" @default.
• W2783117803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29322620" @default.
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