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- W2783118948 abstract "Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress. Biomimetic studies suggest that the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) offers protection in extreme environmental conditions and promotes longevity in the animal kingdom. Similarly, during months of fasting, immobilization and anuria, hibernating bears are protected from muscle wasting, azotaemia, thrombotic complications, organ damage and osteoporosis - features that are often associated with CKD. Improved understanding of the susceptibility and protective mechanisms of these animals and others could provide insights into novel strategies to prevent and treat several human diseases, such as CKD and ageing-associated complications. An integrated collaboration between nephrologists and experts from other fields, such as veterinarians, zoologists, biologists, anthropologists and ecologists, could introduce a novel approach for improving human health and help nephrologists to find novel treatment strategies for CKD." @default.
- W2783118948 created "2018-01-26" @default.
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- W2783118948 date "2018-01-15" @default.
- W2783118948 modified "2023-09-30" @default.
- W2783118948 title "Novel treatment strategies for chronic kidney disease: insights from the animal kingdom" @default.
- W2783118948 cites W1104912482 @default.
- W2783118948 cites W1274402784 @default.
- W2783118948 cites W134119096 @default.
- W2783118948 cites W1421415727 @default.
- W2783118948 cites W1452929828 @default.
- W2783118948 cites W1481383813 @default.
- W2783118948 cites W1516791947 @default.
- W2783118948 cites W1535345430 @default.
- W2783118948 cites W1551352726 @default.
- W2783118948 cites W1586558196 @default.
- W2783118948 cites W1605667856 @default.
- W2783118948 cites W1708128628 @default.
- W2783118948 cites W1760008057 @default.
- W2783118948 cites W1806145471 @default.
- W2783118948 cites W1810577659 @default.
- W2783118948 cites W1840422323 @default.
- W2783118948 cites W1928247921 @default.
- W2783118948 cites W1935077285 @default.
- W2783118948 cites W1939988777 @default.
- W2783118948 cites W1959979104 @default.
- W2783118948 cites W1965366272 @default.
- W2783118948 cites W1966206163 @default.
- W2783118948 cites W1967874682 @default.
- W2783118948 cites W1971313993 @default.
- W2783118948 cites W1972154192 @default.
- W2783118948 cites W1975801164 @default.
- W2783118948 cites W1976928448 @default.
- W2783118948 cites W1978620738 @default.
- W2783118948 cites W1979488224 @default.
- W2783118948 cites W1981520097 @default.
- W2783118948 cites W1983883185 @default.
- W2783118948 cites W1987314503 @default.
- W2783118948 cites W1988598164 @default.
- W2783118948 cites W1989273717 @default.
- W2783118948 cites W1991451606 @default.
- W2783118948 cites W1992544914 @default.
- W2783118948 cites W1996978408 @default.
- W2783118948 cites W1997110756 @default.
- W2783118948 cites W1998495289 @default.
- W2783118948 cites W2000511600 @default.
- W2783118948 cites W2000577735 @default.
- W2783118948 cites W2001172802 @default.
- W2783118948 cites W2004187846 @default.
- W2783118948 cites W2004610574 @default.
- W2783118948 cites W2006242918 @default.
- W2783118948 cites W2007488057 @default.
- W2783118948 cites W2008320064 @default.
- W2783118948 cites W2008558830 @default.
- W2783118948 cites W2008947920 @default.
- W2783118948 cites W2011024719 @default.
- W2783118948 cites W2011430059 @default.
- W2783118948 cites W2012186024 @default.
- W2783118948 cites W2012230387 @default.
- W2783118948 cites W2013225378 @default.
- W2783118948 cites W2016946333 @default.
- W2783118948 cites W2018646519 @default.
- W2783118948 cites W2021215174 @default.
- W2783118948 cites W2021829052 @default.
- W2783118948 cites W2022406714 @default.
- W2783118948 cites W2024608772 @default.
- W2783118948 cites W2025170983 @default.
- W2783118948 cites W2026965367 @default.
- W2783118948 cites W2028723301 @default.
- W2783118948 cites W2029133250 @default.
- W2783118948 cites W2029399130 @default.
- W2783118948 cites W2030187637 @default.
- W2783118948 cites W2030775659 @default.
- W2783118948 cites W2032017095 @default.
- W2783118948 cites W2033458606 @default.
- W2783118948 cites W2033461907 @default.
- W2783118948 cites W2033709172 @default.
- W2783118948 cites W2033801646 @default.
- W2783118948 cites W2034053655 @default.
- W2783118948 cites W2034819178 @default.
- W2783118948 cites W2037104078 @default.
- W2783118948 cites W2037475970 @default.
- W2783118948 cites W2040544793 @default.
- W2783118948 cites W2040841655 @default.
- W2783118948 cites W2041572943 @default.
- W2783118948 cites W2042336965 @default.
- W2783118948 cites W2043325685 @default.
- W2783118948 cites W2044636142 @default.
- W2783118948 cites W2044638285 @default.
- W2783118948 cites W2045371968 @default.
- W2783118948 cites W2051567300 @default.