FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783121179> ?p ?o ?g. }

• W2783121179 endingPage "2313" @default.
• W2783121179 startingPage "2281" @default.
• W2783121179 abstract "Anemia management with erythropoiesis stimulating agents is a challenging task in hemodialysis patients since their response to treatment varies highly. In general, it is difficult to achieve and maintain the predefined hemoglobin (Hgb) target levels in clinical practice. The aim of this study is to develop a fully personalizable controller scheme to stabilize Hgb levels within a narrow target window while keeping drug doses low to mitigate side effects. First in-silico results of this framework are presented in this paper. Based on a model of erythropoiesis we formulate a non-linear model predictive control (NMPC) algorithm for the individualized optimization of epoetin alfa (EPO) doses. Previous to this work, model parameters were estimated for individual patients using clinical data. The optimal control problem is formulated for a continuous drug administration. This is currently a hypothetical form of drug administration for EPO as it would require a programmable EPO pump similar to insulin pumps used to treat patients with diabetes mellitus. In each step of the NMPC method the open-loop problem is solved with a projected quasi-Newton method. The controller is successfully tested in-silico on several patient parameter sets. An appropriate control is feasible in the tested patients under the assumption that the controlled quantity is measured regularly and that continuous EPO administration is adjusted on a daily, weekly or monthly basis. Further, the controller satisfactorily handles the following challenging problems in simulations: bleedings, missed administrations and dosing errors." @default.
• W2783121179 created "2018-01-26" @default.
• W2783121179 creator A5011848948 @default.
• W2783121179 creator A5014189967 @default.
• W2783121179 creator A5022002223 @default.
• W2783121179 creator A5054865846 @default.
• W2783121179 creator A5079217252 @default.
• W2783121179 date "2019-10-19" @default.
• W2783121179 modified "2023-10-06" @default.
• W2783121179 title "Optimal EPO dosing in hemodialysis patients using a non-linear model predictive control approach" @default.
• W2783121179 cites W1977788733 @default.
• W2783121179 cites W1982950315 @default.
• W2783121179 cites W1990952217 @default.
• W2783121179 cites W1993528393 @default.
• W2783121179 cites W2001273251 @default.
• W2783121179 cites W2015985912 @default.
• W2783121179 cites W2038820420 @default.
• W2783121179 cites W2042355592 @default.
• W2783121179 cites W2055007388 @default.
• W2783121179 cites W2090564671 @default.
• W2783121179 cites W2098255331 @default.
• W2783121179 cites W2109223284 @default.
• W2783121179 cites W2123224804 @default.
• W2783121179 cites W2128626254 @default.
• W2783121179 cites W2151798252 @default.
• W2783121179 cites W2160581087 @default.
• W2783121179 cites W2165551972 @default.
• W2783121179 cites W2293616896 @default.
• W2783121179 cites W2582448494 @default.
• W2783121179 cites W2596955988 @default.
• W2783121179 cites W276796924 @default.
• W2783121179 cites W2802794838 @default.
• W2783121179 doi "https://doi.org/10.1007/s00285-019-01429-1" @default.
• W2783121179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6858911" @default.
• W2783121179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31630225" @default.
• W2783121179 hasPublicationYear "2019" @default.
• W2783121179 type Work @default.
• W2783121179 sameAs 2783121179 @default.
• W2783121179 citedByCount "12" @default.
• W2783121179 countsByYear W27831211792020 @default.
• W2783121179 countsByYear W27831211792021 @default.
• W2783121179 countsByYear W27831211792022 @default.
• W2783121179 countsByYear W27831211792023 @default.
• W2783121179 crossrefType "journal-article" @default.
• W2783121179 hasAuthorship W2783121179A5011848948 @default.
• W2783121179 hasAuthorship W2783121179A5014189967 @default.
• W2783121179 hasAuthorship W2783121179A5022002223 @default.
• W2783121179 hasAuthorship W2783121179A5054865846 @default.
• W2783121179 hasAuthorship W2783121179A5079217252 @default.
• W2783121179 hasBestOaLocation W27831211791 @default.
• W2783121179 hasConcept C126322002 @default.
• W2783121179 hasConcept C154945302 @default.
• W2783121179 hasConcept C172205157 @default.
• W2783121179 hasConcept C203479927 @default.
• W2783121179 hasConcept C2775924081 @default.
• W2783121179 hasConcept C2776164570 @default.
• W2783121179 hasConcept C2777288759 @default.
• W2783121179 hasConcept C2778063415 @default.
• W2783121179 hasConcept C2778248108 @default.
• W2783121179 hasConcept C2778534260 @default.
• W2783121179 hasConcept C2779703530 @default.
• W2783121179 hasConcept C41008148 @default.
• W2783121179 hasConcept C47446073 @default.
• W2783121179 hasConcept C6557445 @default.
• W2783121179 hasConcept C71924100 @default.
• W2783121179 hasConcept C86803240 @default.
• W2783121179 hasConceptScore W2783121179C126322002 @default.
• W2783121179 hasConceptScore W2783121179C154945302 @default.
• W2783121179 hasConceptScore W2783121179C172205157 @default.
• W2783121179 hasConceptScore W2783121179C203479927 @default.
• W2783121179 hasConceptScore W2783121179C2775924081 @default.
• W2783121179 hasConceptScore W2783121179C2776164570 @default.
• W2783121179 hasConceptScore W2783121179C2777288759 @default.
• W2783121179 hasConceptScore W2783121179C2778063415 @default.
• W2783121179 hasConceptScore W2783121179C2778248108 @default.
• W2783121179 hasConceptScore W2783121179C2778534260 @default.
• W2783121179 hasConceptScore W2783121179C2779703530 @default.
• W2783121179 hasConceptScore W2783121179C41008148 @default.
• W2783121179 hasConceptScore W2783121179C47446073 @default.
• W2783121179 hasConceptScore W2783121179C6557445 @default.
• W2783121179 hasConceptScore W2783121179C71924100 @default.
• W2783121179 hasConceptScore W2783121179C86803240 @default.
• W2783121179 hasIssue "6-7" @default.
• W2783121179 hasLocation W27831211791 @default.
• W2783121179 hasLocation W27831211792 @default.
• W2783121179 hasLocation W27831211793 @default.
• W2783121179 hasLocation W27831211794 @default.
• W2783121179 hasLocation W27831211795 @default.
• W2783121179 hasLocation W27831211796 @default.
• W2783121179 hasOpenAccess W2783121179 @default.
• W2783121179 hasPrimaryLocation W27831211791 @default.
• W2783121179 hasRelatedWork W1590171812 @default.
• W2783121179 hasRelatedWork W1983279758 @default.
• W2783121179 hasRelatedWork W2007053419 @default.
• W2783121179 hasRelatedWork W2014074349 @default.
• W2783121179 hasRelatedWork W2093825344 @default.
• W2783121179 hasRelatedWork W2302286283 @default.
• W2783121179 hasRelatedWork W2333405720 @default.

• next