FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783121278> ?p ?o ?g. }

• W2783121278 endingPage "658" @default.
• W2783121278 startingPage "651" @default.
• W2783121278 abstract "Background and purpose Genetic research in multiple sclerosis ( MS ) mostly compares patients with MS with healthy controls, but does not differentiate between MS disease courses. We compared peripheral blood gene expression patterns between extremes of MS phenotypes, i.e. patients with mild relapsing‐remitting MS ( mRRMS ) and primary progressive MS ( PPMS ). Methods We analyzed global gene expression profiles of peripheral blood samples of age‐ and gender‐matched patients with mRRMS and PPMS . Detailed bioinformatic and gene set enrichment analysis, pathway and principle component analyses were used to identify differentially expressed genes and pathways. Results A total of 84 genes were significantly deregulated between the groups. Of those, 19 had been previously reported to be deregulated in patients with MS as compared with healthy controls, including major histocompatibility complex, interferon receptor 2 and interleukin 6 receptor. Detailed molecular pathway analysis revealed significant up‐regulation of antigen processing and presentation, leukocyte transendothelial migration, nucleotide‐binding oligomerization domain‐like receptor signaling, chemokine signaling and down‐regulation of RNA transport, spliceosome and aminoacyl‐ tRNA biosynthesis pathways in PPMS compared with mRRMS . Conclusion Our analyses show significant differences between mRRMS and PPMS gene expression. Surprisingly, the differentially expressed genes were mostly involved in immunological and inflammatory pathways, suggesting that the difference in MS phenotypes is caused primarily by a difference in immune responses. It should be kept in mind that our analyses were in peripheral blood only, and that the observed differences in inflammatory pathways may be a substrate of the analysed tissue. Further research into gene expression differences between disease courses including analyses in central nervous system tissue is warranted." @default.
• W2783121278 created "2018-01-26" @default.
• W2783121278 creator A5006635269 @default.
• W2783121278 creator A5007367251 @default.
• W2783121278 creator A5015793767 @default.
• W2783121278 creator A5080958470 @default.
• W2783121278 creator A5085566077 @default.
• W2783121278 creator A5091803230 @default.
• W2783121278 date "2018-02-13" @default.
• W2783121278 modified "2023-09-26" @default.
• W2783121278 title "Global transcriptome profiling of mild relapsing-remitting versus primary progressive multiple sclerosis" @default.
• W2783121278 cites W1546952499 @default.
• W2783121278 cites W1972752407 @default.
• W2783121278 cites W1973094248 @default.
• W2783121278 cites W1986921623 @default.
• W2783121278 cites W1990040006 @default.
• W2783121278 cites W2005100134 @default.
• W2783121278 cites W2025697993 @default.
• W2783121278 cites W2040547343 @default.
• W2783121278 cites W2047062145 @default.
• W2783121278 cites W2060880575 @default.
• W2783121278 cites W2077544385 @default.
• W2783121278 cites W2081098333 @default.
• W2783121278 cites W2088377755 @default.
• W2783121278 cites W2105786767 @default.
• W2783121278 cites W2106608030 @default.
• W2783121278 cites W2110065044 @default.
• W2783121278 cites W2117259705 @default.
• W2783121278 cites W2120865735 @default.
• W2783121278 cites W2122545833 @default.
• W2783121278 cites W2135403800 @default.
• W2783121278 cites W2136737474 @default.
• W2783121278 cites W2139344244 @default.
• W2783121278 cites W2141224543 @default.
• W2783121278 cites W2149541458 @default.
• W2783121278 cites W2159096710 @default.
• W2783121278 cites W2160697532 @default.
• W2783121278 cites W2161929126 @default.
• W2783121278 cites W2515246389 @default.
• W2783121278 cites W4250145052 @default.
• W2783121278 doi "https://doi.org/10.1111/ene.13565" @default.
• W2783121278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29316044" @default.
• W2783121278 hasPublicationYear "2018" @default.
• W2783121278 type Work @default.
• W2783121278 sameAs 2783121278 @default.
• W2783121278 citedByCount "12" @default.
• W2783121278 countsByYear W27831212782018 @default.
• W2783121278 countsByYear W27831212782019 @default.
• W2783121278 countsByYear W27831212782020 @default.
• W2783121278 countsByYear W27831212782021 @default.
• W2783121278 countsByYear W27831212782023 @default.
• W2783121278 crossrefType "journal-article" @default.
• W2783121278 hasAuthorship W2783121278A5006635269 @default.
• W2783121278 hasAuthorship W2783121278A5007367251 @default.
• W2783121278 hasAuthorship W2783121278A5015793767 @default.
• W2783121278 hasAuthorship W2783121278A5080958470 @default.
• W2783121278 hasAuthorship W2783121278A5085566077 @default.
• W2783121278 hasAuthorship W2783121278A5091803230 @default.
• W2783121278 hasConcept C104317684 @default.
• W2783121278 hasConcept C108249834 @default.
• W2783121278 hasConcept C127716648 @default.
• W2783121278 hasConcept C13373296 @default.
• W2783121278 hasConcept C150194340 @default.
• W2783121278 hasConcept C162317418 @default.
• W2783121278 hasConcept C18431079 @default.
• W2783121278 hasConcept C203014093 @default.
• W2783121278 hasConcept C2776090121 @default.
• W2783121278 hasConcept C2779018089 @default.
• W2783121278 hasConcept C2780640218 @default.
• W2783121278 hasConcept C54355233 @default.
• W2783121278 hasConcept C71924100 @default.
• W2783121278 hasConcept C83464605 @default.
• W2783121278 hasConcept C86803240 @default.
• W2783121278 hasConcept C8891405 @default.
• W2783121278 hasConcept C9927688 @default.
• W2783121278 hasConceptScore W2783121278C104317684 @default.
• W2783121278 hasConceptScore W2783121278C108249834 @default.
• W2783121278 hasConceptScore W2783121278C127716648 @default.
• W2783121278 hasConceptScore W2783121278C13373296 @default.
• W2783121278 hasConceptScore W2783121278C150194340 @default.
• W2783121278 hasConceptScore W2783121278C162317418 @default.
• W2783121278 hasConceptScore W2783121278C18431079 @default.
• W2783121278 hasConceptScore W2783121278C203014093 @default.
• W2783121278 hasConceptScore W2783121278C2776090121 @default.
• W2783121278 hasConceptScore W2783121278C2779018089 @default.
• W2783121278 hasConceptScore W2783121278C2780640218 @default.
• W2783121278 hasConceptScore W2783121278C54355233 @default.
• W2783121278 hasConceptScore W2783121278C71924100 @default.
• W2783121278 hasConceptScore W2783121278C83464605 @default.
• W2783121278 hasConceptScore W2783121278C86803240 @default.
• W2783121278 hasConceptScore W2783121278C8891405 @default.
• W2783121278 hasConceptScore W2783121278C9927688 @default.
• W2783121278 hasIssue "4" @default.
• W2783121278 hasLocation W27831212781 @default.
• W2783121278 hasLocation W27831212782 @default.
• W2783121278 hasOpenAccess W2783121278 @default.
• W2783121278 hasPrimaryLocation W27831212781 @default.
• W2783121278 hasRelatedWork W1971124177 @default.

• next