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• W2783125229 abstract "The study aimed to investigate the impact of miR‐182 and FOXO1 on S. japonica ‐induced hepatic fibrosis. Microarray analysis was performed to screen out differential expressed miRNAs and mRNAs. Rat hepatic fibrosis model and human hepatocellular cell line LX‐2 were used to study the effect of miR‐182 and FOXO1 . qRT‐PCR and Western blot were used to detect the expression of miR‐182, FOXO1 or other fibrosis markers. The targeting relationship between FOXO1 and miR‐182 was verified by luciferase reporter assay. Immunohistochemistry or immunofluorescence staining was conducted to detect FOXO1 or α‐SMA in rat hepatic tissues. Cell viability and apoptosis were detected by MTT assay and flow cytometry. The expression of PI3K / AKT pathway‐related proteins was detected by Western blot. miR‐182 was highly expressed in liver fibrosis samples, and FOXO1 expression was negatively correlated with miR‐182 expression. After transfection of miR‐182, FOXO1 expression was down‐regulated, with the results of LX‐2 cells proliferation inhibition and apoptosis induction, as well as the aggravation of rat hepatic fibrosis. The expression of p‐AKT/AKT and p‐S6/S6 was increased, meaning that the PI3K / AKT signal pathway was activated. The results were reversed when treated with Wortmannin ( PI3K inhibitor). After transfection of miR‐182 inhibitor, FOXO1 expression was up‐regulated, LX‐2 cell proliferation was inhibited, and apoptosis rate was increased. High‐expressed miR‐182 and low‐expressed FOXO1 promoted proliferation and inhibiting apoptosis on liver fibrosis cells, stimulating the development of S. japonica ‐induced hepatic fibrosis through feeding back to PI3K/AKT signaling pathway." @default.
• W2783125229 created "2018-01-26" @default.
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• W2783125229 date "2018-04-25" @default.
• W2783125229 modified "2023-09-30" @default.
• W2783125229 title "Effect of miR‐182 on hepatic fibrosis induced by <i>Schistosomiasis japonica</i> by targeting <i>FOXO1</i> through <i>PI3K</i> / <i>AKT</i> signaling pathway" @default.
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• W2783125229 doi "https://doi.org/10.1002/jcp.26469" @default.
• W2783125229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29323718" @default.
• W2783125229 hasPublicationYear "2018" @default.
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