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- W2783126247 abstract "The present study is to develop a pharmaceutically stable and quality improved formulation of Metoprolol succinate extended release pellets. To achieve this goal various prototype formulation trials were formulated and theevaluated with respect to the various quality controls such as dissolution, assay and stability studies will be under taken. The primary objective of this study is to prepare drug loaded pellets of metoprolol succinate (MS) using solution layering technology, and to give functionalcoating of pellets with ethyl cellulose (EC), in the present study EC is used due to its convenient film formability, good physicochemical properties and minimum toxicity.HPMC confers the film a more hydrophilic nature and alters its structure by virtue of pores and channels through which the substance can diffuse more easily to control therelease properties of drug formulation. The coating parameters like batch size, pan rpm, spray pattern and temperature of the bed were optimized in order to get efficient drug loading and uniform functional coating. Metoprolol succinate is used in the treatment of hypertension, chest pain (angina pectoris) and myocardial infraction either alone or in combination with other drugs.Pellets are of great interest to the pharmaceutical industry for various reasons. Pelletized product not only offers flexibility in dosage form design and development,but also utilized to improve safety and efficacy of bioactive agent. A multiunit pellet system (MUPS) is an approach to develop capsule formulation, capsule containingMUPS, when administered drug dispersed in it. Each pellet acts a single unit. Consequently as a separate drug delivery system. The MUPS have god desirable distribution characteristics, reproducibility, transit time and reduce chance of localization of drug delivery. It is having less prone to adherence to the intestinal walls, naso-gastric and gastromy tubes and giving predictable delivery of the product to the site of drug release. the Metoprolol succinate pellets MSER F7 are prepared and these showed good physico-chemical properties and the dissolution results showed satisfactory results when compared with theinnovator drug." @default.
- W2783126247 created "2018-01-26" @default.
- W2783126247 creator A5062889919 @default.
- W2783126247 date "2012-05-01" @default.
- W2783126247 modified "2023-09-26" @default.
- W2783126247 title "Formulation and Evaluation of Metoprolol Succinate Extended Release Pellets." @default.
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- W2783126247 hasPublicationYear "2012" @default.
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