Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783131976> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2783131976 endingPage "37" @default.
- W2783131976 startingPage "34" @default.
- W2783131976 abstract "Hyperlipidemia is a major risk factor for coronary heart diseases and ischemia that leading to high rates of mortalities. Conventionally, hyperlipidemia is managed using agents that facilitate the clearance of total cholesterol (TC), triacylglycerides (TAG) and low density lipoprotein (LDL) from the body. Despite the use of these drugs, the disease still remained a global burden that affects the quality of life. The current study was done to investigate hypolipidemic properties of the methanolic extract of Boswellia dalzielli hutch (MEBDH) stem bark in rodents. The phytochemicals of the MEBDH were screened and determined qualitatively before performing acute toxicity study to determine the LD50 of the extract. Twenty five male albino rats 2-3 months old (150-210) g were distributed randomly into five groups [Group 1: normal control received 200 μL normal saline daily for 3 weeks, Group 2: hyperlipidemic control induced by a single dose of Triton X-100 (150 mg/kg body weight) subcutaneously, followed by oral administration of 200 μL normal saline daily for 3 weeks. Group 2 and 4: hyperlipidemic rats treated orally with MEBDH (200 and 400 mg/kg body weight) respectively for 21 days. Group 5: hyperlipidemic rats treated with Simvastatin (5 mg/kg body weight) daily throughout the experimental period as positive control]. Administration of the extract did not cause any mortality regardless of the dose. However, the extract caused significant (p<0.05) decrease in TC, TAG and LDL-cholesterol levels in the treated rats. The decrease observed is significantly lower than that of untreated rats. In contrast, the level of HDL increased significantly (p<0.05) after treating the rats with the MEBDH stem bark. The extract of MEBDH possessed hypolipidemic agents and could be the potential substitute hyperlipidemic agents with side effect. Keywords: Albino Rats, Atherosclerosis, Boswellia dalzielli hutch, Coronary Heart Disease, Hyperlipidemia, Triton X100" @default.
- W2783131976 created "2018-01-26" @default.
- W2783131976 creator A5013271515 @default.
- W2783131976 creator A5039310017 @default.
- W2783131976 creator A5047898428 @default.
- W2783131976 creator A5058651671 @default.
- W2783131976 creator A5058904969 @default.
- W2783131976 creator A5067949842 @default.
- W2783131976 creator A5076301807 @default.
- W2783131976 date "2017-12-31" @default.
- W2783131976 modified "2023-09-26" @default.
- W2783131976 title "IN VIVO AMELIORATIVE EFFECT OF METHANOLIC EXTRACT OF BOSWELLIA DALZIELLI HUTCH (MEBDH) STEM BARK ON TRITON X-100 INDUCED HYPERLIPIDAEMIA" @default.
- W2783131976 cites W1488979321 @default.
- W2783131976 cites W1928802446 @default.
- W2783131976 cites W1976168213 @default.
- W2783131976 cites W1993043109 @default.
- W2783131976 cites W2043042777 @default.
- W2783131976 cites W2063700981 @default.
- W2783131976 cites W2082580535 @default.
- W2783131976 cites W2128738470 @default.
- W2783131976 cites W3015241329 @default.
- W2783131976 cites W3025790179 @default.
- W2783131976 cites W338188938 @default.
- W2783131976 hasPublicationYear "2017" @default.
- W2783131976 type Work @default.
- W2783131976 sameAs 2783131976 @default.
- W2783131976 citedByCount "0" @default.
- W2783131976 crossrefType "journal-article" @default.
- W2783131976 hasAuthorship W2783131976A5013271515 @default.
- W2783131976 hasAuthorship W2783131976A5039310017 @default.
- W2783131976 hasAuthorship W2783131976A5047898428 @default.
- W2783131976 hasAuthorship W2783131976A5058651671 @default.
- W2783131976 hasAuthorship W2783131976A5058904969 @default.
- W2783131976 hasAuthorship W2783131976A5067949842 @default.
- W2783131976 hasAuthorship W2783131976A5076301807 @default.
- W2783131976 hasConcept C126322002 @default.
- W2783131976 hasConcept C134018914 @default.
- W2783131976 hasConcept C147583825 @default.
- W2783131976 hasConcept C150903083 @default.
- W2783131976 hasConcept C207001950 @default.
- W2783131976 hasConcept C2776329913 @default.
- W2783131976 hasConcept C2777056448 @default.
- W2783131976 hasConcept C2777397205 @default.
- W2783131976 hasConcept C2778163477 @default.
- W2783131976 hasConcept C2778913445 @default.
- W2783131976 hasConcept C2779091943 @default.
- W2783131976 hasConcept C555293320 @default.
- W2783131976 hasConcept C556039675 @default.
- W2783131976 hasConcept C71924100 @default.
- W2783131976 hasConcept C86803240 @default.
- W2783131976 hasConcept C98274493 @default.
- W2783131976 hasConceptScore W2783131976C126322002 @default.
- W2783131976 hasConceptScore W2783131976C134018914 @default.
- W2783131976 hasConceptScore W2783131976C147583825 @default.
- W2783131976 hasConceptScore W2783131976C150903083 @default.
- W2783131976 hasConceptScore W2783131976C207001950 @default.
- W2783131976 hasConceptScore W2783131976C2776329913 @default.
- W2783131976 hasConceptScore W2783131976C2777056448 @default.
- W2783131976 hasConceptScore W2783131976C2777397205 @default.
- W2783131976 hasConceptScore W2783131976C2778163477 @default.
- W2783131976 hasConceptScore W2783131976C2778913445 @default.
- W2783131976 hasConceptScore W2783131976C2779091943 @default.
- W2783131976 hasConceptScore W2783131976C555293320 @default.
- W2783131976 hasConceptScore W2783131976C556039675 @default.
- W2783131976 hasConceptScore W2783131976C71924100 @default.
- W2783131976 hasConceptScore W2783131976C86803240 @default.
- W2783131976 hasConceptScore W2783131976C98274493 @default.
- W2783131976 hasIssue "4" @default.
- W2783131976 hasLocation W27831319761 @default.
- W2783131976 hasOpenAccess W2783131976 @default.
- W2783131976 hasPrimaryLocation W27831319761 @default.
- W2783131976 hasRelatedWork W1549455096 @default.
- W2783131976 hasRelatedWork W2142373574 @default.
- W2783131976 hasRelatedWork W2146508462 @default.
- W2783131976 hasRelatedWork W2183634774 @default.
- W2783131976 hasRelatedWork W2188633662 @default.
- W2783131976 hasRelatedWork W2519486669 @default.
- W2783131976 hasRelatedWork W2582826742 @default.
- W2783131976 hasRelatedWork W2591741321 @default.
- W2783131976 hasRelatedWork W2614776038 @default.
- W2783131976 hasRelatedWork W2791437043 @default.
- W2783131976 hasRelatedWork W2945621167 @default.
- W2783131976 hasRelatedWork W2992902214 @default.
- W2783131976 hasRelatedWork W2993828559 @default.
- W2783131976 hasRelatedWork W3016890572 @default.
- W2783131976 hasRelatedWork W3107489885 @default.
- W2783131976 hasRelatedWork W3119571015 @default.
- W2783131976 hasRelatedWork W3139594582 @default.
- W2783131976 hasRelatedWork W3198828025 @default.
- W2783131976 hasRelatedWork W2183198922 @default.
- W2783131976 hasRelatedWork W2462680122 @default.
- W2783131976 hasVolume "12" @default.
- W2783131976 isParatext "false" @default.
- W2783131976 isRetracted "false" @default.
- W2783131976 magId "2783131976" @default.
- W2783131976 workType "article" @default.