Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783132795> ?p ?o ?g. }
- W2783132795 endingPage "726" @default.
- W2783132795 startingPage "717" @default.
- W2783132795 abstract "Background This work evaluates the consistency, effect size and incidence of persistent side effects of lesional neurosurgical interventions in the treatment of tremor due to Parkinson’s disease (PD), essential tremor (ET), multiple sclerosis (MS) and midbrain lesions. Methods Systematic review and meta-analysis according to PRISMA-P guidelines. Random effects meta-analysis of standardised mean difference based on a peer-reviewed protocol (PROSPERO no. CRD42016048049). Results From 1249 abstracts screened, 86 peer-reviewed studies reporting 102 cohorts homogeneous for tremor aetiology, surgical target and technique were included. Effect on PD tremor was better when targeted at the ventral intermediate nucleus (V.im.) by radiofrequency ablation (RF) (Hedge’s g: −4.15;) over V.im. by Gamma Knife (GK) (−2.2), subthalamic nucleus (STN) by RF (−1.12) and globus pallidus internus (GPi) by RF (−0.89). For ET MRI-guided focused ultrasound (MRIgFUS) ablation of the cerebellothalamic tract (CTT) (−2.35) and V.im. (−2.08) showed similar mean tremor reductions to V.im. ablation by RF (−2.42) or GK (−2.13). In MS V.im. ablation by GK (−1.96) and RF (−1.63) were similarly effective. Mean rates of persistent side effects after unilateral lesions in PD were 12.8% (RF V.im.), 13.6% (RF STN), 9.2% (RF GPi), 0.7% (GK V.im.) and 7.0% (MRIgFUS V.im.). For ET, rates were 9.3% (RF V.im.), 1.8% (GK V.im.), 18.7% (MRIgFUS V.im.) and 0.0% (MRIgFUS CTT), for MS 37.7% (RF V.im.) and for rubral tremor 30.3% (RF V.im.). Conclusion This meta-analysis quantifies safety, consistency and efficacy of lesional neurosurgical interventions for tremor by target, technique and aetiology." @default.
- W2783132795 created "2018-01-26" @default.
- W2783132795 creator A5025356444 @default.
- W2783132795 creator A5044208679 @default.
- W2783132795 creator A5071626950 @default.
- W2783132795 creator A5089591112 @default.
- W2783132795 creator A5090019636 @default.
- W2783132795 date "2018-01-11" @default.
- W2783132795 modified "2023-09-30" @default.
- W2783132795 title "Functional lesional neurosurgery for tremor: a systematic review and meta-analysis" @default.
- W2783132795 cites W1563614294 @default.
- W2783132795 cites W1582744819 @default.
- W2783132795 cites W1709447044 @default.
- W2783132795 cites W1965771755 @default.
- W2783132795 cites W1971255930 @default.
- W2783132795 cites W1973007182 @default.
- W2783132795 cites W1976123900 @default.
- W2783132795 cites W1977232089 @default.
- W2783132795 cites W1977569087 @default.
- W2783132795 cites W1978641571 @default.
- W2783132795 cites W1980178850 @default.
- W2783132795 cites W1980568315 @default.
- W2783132795 cites W1985319523 @default.
- W2783132795 cites W1986059795 @default.
- W2783132795 cites W1986215651 @default.
- W2783132795 cites W1990052942 @default.
- W2783132795 cites W1990345877 @default.
- W2783132795 cites W1991106943 @default.
- W2783132795 cites W1991589426 @default.
- W2783132795 cites W1993936388 @default.
- W2783132795 cites W1995604247 @default.
- W2783132795 cites W2003142120 @default.
- W2783132795 cites W2005422033 @default.
- W2783132795 cites W2007528784 @default.
- W2783132795 cites W2010192674 @default.
- W2783132795 cites W2010705737 @default.
- W2783132795 cites W2017358575 @default.
- W2783132795 cites W2019465732 @default.
- W2783132795 cites W2020942995 @default.
- W2783132795 cites W2022593912 @default.
- W2783132795 cites W2023117146 @default.
- W2783132795 cites W2024347935 @default.
- W2783132795 cites W2025850077 @default.
- W2783132795 cites W2035996556 @default.
- W2783132795 cites W2040065426 @default.
- W2783132795 cites W2044217050 @default.
- W2783132795 cites W2044433374 @default.
- W2783132795 cites W2048111789 @default.
- W2783132795 cites W2048512548 @default.
- W2783132795 cites W2050436219 @default.
- W2783132795 cites W2061017418 @default.
- W2783132795 cites W2062865989 @default.
- W2783132795 cites W2063004315 @default.
- W2783132795 cites W2064647873 @default.
- W2783132795 cites W2065267852 @default.
- W2783132795 cites W2071723217 @default.
- W2783132795 cites W2073956340 @default.
- W2783132795 cites W2074611475 @default.
- W2783132795 cites W2080653245 @default.
- W2783132795 cites W2085597774 @default.
- W2783132795 cites W2086996941 @default.
- W2783132795 cites W2087565659 @default.
- W2783132795 cites W2098622858 @default.
- W2783132795 cites W2103399773 @default.
- W2783132795 cites W2109007545 @default.
- W2783132795 cites W2114075597 @default.
- W2783132795 cites W2115554516 @default.
- W2783132795 cites W2118057158 @default.
- W2783132795 cites W2128820615 @default.
- W2783132795 cites W2129512856 @default.
- W2783132795 cites W2131092265 @default.
- W2783132795 cites W2131979090 @default.
- W2783132795 cites W2138807698 @default.
- W2783132795 cites W2139267748 @default.
- W2783132795 cites W2139484893 @default.
- W2783132795 cites W2144380751 @default.
- W2783132795 cites W2145972863 @default.
- W2783132795 cites W2151235301 @default.
- W2783132795 cites W2159144035 @default.
- W2783132795 cites W2162607528 @default.
- W2783132795 cites W2165232227 @default.
- W2783132795 cites W2169134951 @default.
- W2783132795 cites W2169205464 @default.
- W2783132795 cites W2169897881 @default.
- W2783132795 cites W2170262105 @default.
- W2783132795 cites W2173431927 @default.
- W2783132795 cites W2189028573 @default.
- W2783132795 cites W2253517324 @default.
- W2783132795 cites W2294016834 @default.
- W2783132795 cites W2320389606 @default.
- W2783132795 cites W2339837279 @default.
- W2783132795 cites W2517769867 @default.
- W2783132795 cites W2593505952 @default.
- W2783132795 cites W2604465905 @default.
- W2783132795 cites W2612755260 @default.
- W2783132795 doi "https://doi.org/10.1136/jnnp-2017-316302" @default.
- W2783132795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29326290" @default.
- W2783132795 hasPublicationYear "2018" @default.