Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783133252> ?p ?o ?g. }
- W2783133252 abstract "Abstract Atherosclerosis is characterized by the accumulation of lipids within the arterial wall. Although activation of TRPV1 cation channels by capsaicin may reduce lipid storage and the formation of atherosclerotic lesions, a clinical use for capsaicin has been limited by its chronic toxicity. Here we show that coupling of copper sulfide (CuS) nanoparticles to antibodies targeting TRPV1 act as a photothermal switch for TRPV1 signaling in vascular smooth muscle cells (VSMCs) using near-infrared light. Upon irradiation, local increases of temperature open thermo-sensitive TRPV1 channels and cause Ca 2+ influx. The increase in intracellular Ca 2+ activates autophagy and impedes foam cell formation in VSMCs treated with oxidized low-density lipoprotein. In vivo, CuS-TRPV1 allows photoacoustic imaging of the cardiac vasculature and reduces lipid storage and plaque formation in ApoE − / − mice fed a high-fat diet, with no obvious long-term toxicity. Together, this suggests CuS-TRPV1 may represent a therapeutic tool to locally and temporally attenuate atherosclerosis." @default.
- W2783133252 created "2018-01-26" @default.
- W2783133252 creator A5009256057 @default.
- W2783133252 creator A5030288333 @default.
- W2783133252 creator A5034707336 @default.
- W2783133252 creator A5056588387 @default.
- W2783133252 creator A5064408814 @default.
- W2783133252 creator A5084547403 @default.
- W2783133252 creator A5089117924 @default.
- W2783133252 creator A5090789682 @default.
- W2783133252 date "2018-01-15" @default.
- W2783133252 modified "2023-10-16" @default.
- W2783133252 title "Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis" @default.
- W2783133252 cites W1143482056 @default.
- W2783133252 cites W1523693806 @default.
- W2783133252 cites W1969233157 @default.
- W2783133252 cites W1977109672 @default.
- W2783133252 cites W1983619827 @default.
- W2783133252 cites W1984634349 @default.
- W2783133252 cites W1986805734 @default.
- W2783133252 cites W1989605865 @default.
- W2783133252 cites W1992063755 @default.
- W2783133252 cites W1992723548 @default.
- W2783133252 cites W1993866008 @default.
- W2783133252 cites W1994823455 @default.
- W2783133252 cites W1998591341 @default.
- W2783133252 cites W1998993589 @default.
- W2783133252 cites W2003502533 @default.
- W2783133252 cites W2007262967 @default.
- W2783133252 cites W2007505836 @default.
- W2783133252 cites W2017378233 @default.
- W2783133252 cites W2030964111 @default.
- W2783133252 cites W2033745531 @default.
- W2783133252 cites W2038163024 @default.
- W2783133252 cites W2045936365 @default.
- W2783133252 cites W2048726892 @default.
- W2783133252 cites W2057274775 @default.
- W2783133252 cites W2076719191 @default.
- W2783133252 cites W2076849967 @default.
- W2783133252 cites W2079921510 @default.
- W2783133252 cites W2083437541 @default.
- W2783133252 cites W2085194018 @default.
- W2783133252 cites W2093031772 @default.
- W2783133252 cites W2094925460 @default.
- W2783133252 cites W2094941678 @default.
- W2783133252 cites W2102179496 @default.
- W2783133252 cites W2112272457 @default.
- W2783133252 cites W2124116260 @default.
- W2783133252 cites W2130411419 @default.
- W2783133252 cites W2151485523 @default.
- W2783133252 cites W2159588174 @default.
- W2783133252 cites W2168944768 @default.
- W2783133252 cites W2254581432 @default.
- W2783133252 cites W2285239107 @default.
- W2783133252 cites W2324415512 @default.
- W2783133252 cites W2336249048 @default.
- W2783133252 cites W2418560736 @default.
- W2783133252 doi "https://doi.org/10.1038/s41467-017-02657-z" @default.
- W2783133252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768725" @default.
- W2783133252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29335450" @default.
- W2783133252 hasPublicationYear "2018" @default.
- W2783133252 type Work @default.
- W2783133252 sameAs 2783133252 @default.
- W2783133252 citedByCount "188" @default.
- W2783133252 countsByYear W27831332522018 @default.
- W2783133252 countsByYear W27831332522019 @default.
- W2783133252 countsByYear W27831332522020 @default.
- W2783133252 countsByYear W27831332522021 @default.
- W2783133252 countsByYear W27831332522022 @default.
- W2783133252 countsByYear W27831332522023 @default.
- W2783133252 crossrefType "journal-article" @default.
- W2783133252 hasAuthorship W2783133252A5009256057 @default.
- W2783133252 hasAuthorship W2783133252A5030288333 @default.
- W2783133252 hasAuthorship W2783133252A5034707336 @default.
- W2783133252 hasAuthorship W2783133252A5056588387 @default.
- W2783133252 hasAuthorship W2783133252A5064408814 @default.
- W2783133252 hasAuthorship W2783133252A5084547403 @default.
- W2783133252 hasAuthorship W2783133252A5089117924 @default.
- W2783133252 hasAuthorship W2783133252A5090789682 @default.
- W2783133252 hasBestOaLocation W27831332521 @default.
- W2783133252 hasConcept C12554922 @default.
- W2783133252 hasConcept C126322002 @default.
- W2783133252 hasConcept C155164980 @default.
- W2783133252 hasConcept C160145004 @default.
- W2783133252 hasConcept C170493617 @default.
- W2783133252 hasConcept C171250308 @default.
- W2783133252 hasConcept C182606246 @default.
- W2783133252 hasConcept C185592680 @default.
- W2783133252 hasConcept C190283241 @default.
- W2783133252 hasConcept C192562407 @default.
- W2783133252 hasConcept C203522944 @default.
- W2783133252 hasConcept C2777895019 @default.
- W2783133252 hasConcept C2778163477 @default.
- W2783133252 hasConcept C2779395532 @default.
- W2783133252 hasConcept C2780051329 @default.
- W2783133252 hasConcept C2780072125 @default.
- W2783133252 hasConcept C2992686903 @default.
- W2783133252 hasConcept C55493867 @default.
- W2783133252 hasConcept C71924100 @default.
- W2783133252 hasConcept C79879829 @default.