Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783133530> ?p ?o ?g. }
- W2783133530 endingPage "388" @default.
- W2783133530 startingPage "377" @default.
- W2783133530 abstract "The inflammatory response of glial cells contributes to neuronal damage or repair after brain ischemia/reperfusion insult. We previously demonstrated a protective role of TP53-induced glycolysis and apoptosis regulator (TIGAR) in ischemic neuronal injury through increasing the flow of pentose phosphate pathway (PPP). The present study investigated the possible role of TIGAR in ischemia/reperfusion-induced inflammatory response of astrocytes. Male ICR mice were subjected to middle cerebral artery occlusion for 2 h followed by 24 h reperfusion and cultured primary astrocytes were subjected to oxygen glucose deprivation for 9 h followed by 24 h reoxygenation (OGD/R). Adenoviral vectors were used to alter the levels of TIGAR protein in brain and in culture primary astrocytes. We showed that during the OGD/R insult the protein levels of TIGAR were rapidly increased in astrocytes. Overexpression of TIGAR mediated increased the viability, levels of NADPH and rGSH, and reduced intracellular reactive oxygen species (ROS) in cultured primary astrocytes. Overexpression of TIGAR not only significantly reduced infarct volume after stroke insult but also markedly reduced long-term mortality and improved recovery of neurological functions. Overexpression of TIGAR tempered OGD/R- or ischemia/reperfusion-induced the upregulation of inducible nitric oxide synthase (iNOS), cyclooxygenases COX2 and the release of pro-inflammatory cytokines interleukin 1 beta (IL-1β) and tumor necrosis factor-α (TNF-α), while TIGAR knockdown produced opposite effects on these parameters. Moreover, Overexpression of TIGAR suppressed OGD/R-induced degradation of IκBα and NF-κB nuclear translocation in cultured primary astrocytes. The present study elucidates a novel mechanism by which TIGAR protects neurons against ischemia/reperfusion injury." @default.
- W2783133530 created "2018-01-26" @default.
- W2783133530 creator A5007120063 @default.
- W2783133530 creator A5032740511 @default.
- W2783133530 creator A5033510051 @default.
- W2783133530 creator A5040751828 @default.
- W2783133530 creator A5041287759 @default.
- W2783133530 creator A5046686155 @default.
- W2783133530 creator A5047090672 @default.
- W2783133530 creator A5050455037 @default.
- W2783133530 creator A5069913800 @default.
- W2783133530 creator A5078882383 @default.
- W2783133530 creator A5089749504 @default.
- W2783133530 date "2018-03-01" @default.
- W2783133530 modified "2023-10-17" @default.
- W2783133530 title "TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes" @default.
- W2783133530 cites W139494526 @default.
- W2783133530 cites W1964631090 @default.
- W2783133530 cites W1981855584 @default.
- W2783133530 cites W1982174124 @default.
- W2783133530 cites W1983836947 @default.
- W2783133530 cites W1984305500 @default.
- W2783133530 cites W1990216374 @default.
- W2783133530 cites W1992571619 @default.
- W2783133530 cites W2015243552 @default.
- W2783133530 cites W2016597337 @default.
- W2783133530 cites W2019514271 @default.
- W2783133530 cites W2021715667 @default.
- W2783133530 cites W2026741596 @default.
- W2783133530 cites W2035221144 @default.
- W2783133530 cites W2035637936 @default.
- W2783133530 cites W2041810204 @default.
- W2783133530 cites W2059994807 @default.
- W2783133530 cites W2064080906 @default.
- W2783133530 cites W2071018647 @default.
- W2783133530 cites W2074661552 @default.
- W2783133530 cites W2083288103 @default.
- W2783133530 cites W2096978860 @default.
- W2783133530 cites W2111323052 @default.
- W2783133530 cites W2112505121 @default.
- W2783133530 cites W2116644918 @default.
- W2783133530 cites W2118200665 @default.
- W2783133530 cites W2119239003 @default.
- W2783133530 cites W2120003285 @default.
- W2783133530 cites W2178162055 @default.
- W2783133530 cites W2347079267 @default.
- W2783133530 doi "https://doi.org/10.1016/j.neuropharm.2018.01.012" @default.
- W2783133530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29331305" @default.
- W2783133530 hasPublicationYear "2018" @default.
- W2783133530 type Work @default.
- W2783133530 sameAs 2783133530 @default.
- W2783133530 citedByCount "35" @default.
- W2783133530 countsByYear W27831335302019 @default.
- W2783133530 countsByYear W27831335302020 @default.
- W2783133530 countsByYear W27831335302021 @default.
- W2783133530 countsByYear W27831335302022 @default.
- W2783133530 countsByYear W27831335302023 @default.
- W2783133530 crossrefType "journal-article" @default.
- W2783133530 hasAuthorship W2783133530A5007120063 @default.
- W2783133530 hasAuthorship W2783133530A5032740511 @default.
- W2783133530 hasAuthorship W2783133530A5033510051 @default.
- W2783133530 hasAuthorship W2783133530A5040751828 @default.
- W2783133530 hasAuthorship W2783133530A5041287759 @default.
- W2783133530 hasAuthorship W2783133530A5046686155 @default.
- W2783133530 hasAuthorship W2783133530A5047090672 @default.
- W2783133530 hasAuthorship W2783133530A5050455037 @default.
- W2783133530 hasAuthorship W2783133530A5069913800 @default.
- W2783133530 hasAuthorship W2783133530A5078882383 @default.
- W2783133530 hasAuthorship W2783133530A5089749504 @default.
- W2783133530 hasConcept C126322002 @default.
- W2783133530 hasConcept C134018914 @default.
- W2783133530 hasConcept C17991360 @default.
- W2783133530 hasConcept C185592680 @default.
- W2783133530 hasConcept C190283241 @default.
- W2783133530 hasConcept C203014093 @default.
- W2783133530 hasConcept C2776914184 @default.
- W2783133530 hasConcept C2777542381 @default.
- W2783133530 hasConcept C2777622882 @default.
- W2783133530 hasConcept C2780114680 @default.
- W2783133530 hasConcept C48349386 @default.
- W2783133530 hasConcept C519581460 @default.
- W2783133530 hasConcept C529278444 @default.
- W2783133530 hasConcept C541997718 @default.
- W2783133530 hasConcept C55493867 @default.
- W2783133530 hasConcept C71924100 @default.
- W2783133530 hasConcept C86803240 @default.
- W2783133530 hasConcept C95444343 @default.
- W2783133530 hasConcept C98274493 @default.
- W2783133530 hasConceptScore W2783133530C126322002 @default.
- W2783133530 hasConceptScore W2783133530C134018914 @default.
- W2783133530 hasConceptScore W2783133530C17991360 @default.
- W2783133530 hasConceptScore W2783133530C185592680 @default.
- W2783133530 hasConceptScore W2783133530C190283241 @default.
- W2783133530 hasConceptScore W2783133530C203014093 @default.
- W2783133530 hasConceptScore W2783133530C2776914184 @default.
- W2783133530 hasConceptScore W2783133530C2777542381 @default.
- W2783133530 hasConceptScore W2783133530C2777622882 @default.
- W2783133530 hasConceptScore W2783133530C2780114680 @default.