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• W2783134630 abstract "Drug delivery within the oral cavity may be summarizedunder buccal, sublingual and local delivery. Among the three routesof drug delivery within the oral cavity, sublingual and buccal arefound to be the most effective. Here we have selected buccal drugdelivery system because unlike sublingual, buccal is suitable for oraltransmucosal delivery system. Buccal is a more preferred route, forthe systemic transmucosal drug delivery. The reason that the buccalmucosa has an expanse of smooth muscle and relatively immobilemucosa which makes it a more desirable region for drugs used inoral mucosal drug delivery. Thus, the buccal mucosa is more filledfor delivery of less permeable molecules and perhaps peptide drugs.In this present study, nine different buccal tablets containingnicorandil, using various bioadhesive polymers such as CP, PVP,PVA and EC (backing layer), by two different methods. All the nineformulations were used for the determination of physicochemicalevaluations, in vitro drug release and in vitro dissolution kinetics.From this work, we conclude that F3 (Content: Nicorandil3mg, CP 100mg, PVP 80mg and PVA 50mg) and B2 (Content:Nicorandil 5mg, CP 120mg, PVP 80mg) were found to be idealbuccal tablets, with the highest percentage release of 80.83± 0.93%and 87.0± 1.03%, respectively and we also found that the idealbioadhesive carriers are PVP and PVA, because of high wettabilityof the mucous membrane of the buccal area. Further studies can bedone to improve the buccal delivery system by in vivo permeation studies. They can be employed to examine drug transport acrossbuccal tissues from animal models. Buccal cell cultures have alsobeen suggested as useful in vitro models for buccal drug permeationand metabolism. In vivo methods were first developed by Beckettand Triggs with buccal absorption test, with which the kinetics ofdrug absorption was measured. The drawbacks of this methodinclude salivary dilution of the drug, accidental swallowing a portionof sample solution, and the inability to localize the drug solutionwithin a specific site. Pharmacokinetic parameters such asbioavailability can then be calculated from the plasma concentrationvs time profile.The buccal mucosa offers several advantages for effectivedrug delivery. The mucosa is well supplied with both vascular andlymphatic drainage, first pass metabolism and in the liver andpresystemic elimination in the gastrointestinal tract are avoided.The area is well suited for a retentive device and appears to beacceptable to the patient. With the right dosage form design andformulation, the permeability and the local environment of themucosa can be controlled and manipulated in order to accommodatedrug permeation. Buccal drug delivery is a promising area withcontinued research, with the aim of systemic delivery of orallyinefficient drugs as well as an attractive alternative for non–invasivedelivery of potent peptide and protein drug molecules. Bioadhesivestudies, animal model and in vivo drug release could be carried outto evaluate the performance of prepared buccal tablets of Nicorandil." @default.
• W2783134630 created "2018-01-26" @default.
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• W2783134630 date "2010-03-01" @default.
• W2783134630 modified "2023-09-27" @default.
• W2783134630 title "Development and Evaluation of A Buccal Drug Delivery System for the Anti-Anginal Drug-Nicorandil" @default.
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