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• W2783136339 abstract "Pain is part of our life, existing throughout human development, from birthto death. It is a perception triggered in the nervous system and evoked as a result ofexternal stimuli, disease or tissue damage. Pain is important for survival because itacts as protective and alarm mechanism. According to the International Associationfor the Study of Pain, it is an unpleasant sensory and emotional experienceassociated with potential or actual tissue damage.1It is associated with variousdiseases, inflammatory conditions, tissue damage and surgical interventions. Variousfactors such as physiological, pathological and psychological are involved in painperception. In addition to these factors, various chemical substances are involved inthe modulation and transduction of pain such as 5-hydroxytryptamine, gammaamino butyric acid, acetylcholine, histamine, bradykinin, substance P, opioidpeptides etc.The present study investigated the relation between endogenous insulin leveland pain threshold and its interaction with opioid system and diurnal rhythmin animal model using different nociceptive tests and pentazocine as a modeldrug.We observed significant relation between endogenous insulin level and painthreshold independent of the glycemic status in acetic acid, formalin and tailflick models except in the hot plate model where such a relation seemsdependent on the glycemic status.Insulin appears interacting with opioid receptor (kappa receptor) based onthe preliminary study by protein-protein docking method.Endogenous insulin positively correlate with pain threshold which was foundto be influenced by diurnal rhythm.Endogenous insulin level showed peak in the dark cycle and trough in thelight cycle in all the pain models investigated.The study reports for the first time on the involvement of endogenous insulinin pain threshold against different nociceptive tests in animal models.The above findings clearly delineate that there seems to be no direct relationbetween blood glucose levels and antinociception, however, a possible involvementof endogenous insulin in pain threshold through opioid pathway by binding withkappa receptor which is independent of the glycemic status. The association betweenendogenous insulin and pain threshold seems dependent on the type of nociceptivestimuli and the endogenous insulin level and pain intensities seems influenced bydiurnal rhythm." @default.
• W2783136339 created "2018-01-26" @default.
• W2783136339 creator A5062850656 @default.
• W2783136339 date "2014-03-01" @default.
• W2783136339 modified "2023-09-22" @default.
• W2783136339 title "An Investigation into the Role of Insulin in Pain Threshold" @default.
• W2783136339 hasPublicationYear "2014" @default.
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