Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783136423> ?p ?o ?g. }
- W2783136423 abstract "Abstract Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met- R -SO), is widespread in microorganisms, but during evolution this function, conferred by the enzyme fRMsr, was lost in metazoa. We examined whether restoration of the fRMsr function in an animal can alleviate the consequences of methionine oxidation. Ectopic expression of yeast fRMsr supported the ability of Drosophila to catalyze free Met- R -SO reduction without affecting fecundity, food consumption, and response to starvation. fRMsr expression also increased resistance to oxidative stress. Moreover, it extended lifespan of flies in a methionine-dependent manner. Thus, expression of an oxidoreductase lost during evolution can enhance metabolic and redox functions and lead to an increase in lifespan in an animal model. More broadly, our study exposes the potential of a combination of genetic and nutritional strategies in lifespan control." @default.
- W2783136423 created "2018-01-26" @default.
- W2783136423 creator A5010080171 @default.
- W2783136423 creator A5026769825 @default.
- W2783136423 creator A5031261105 @default.
- W2783136423 creator A5051266855 @default.
- W2783136423 creator A5067909268 @default.
- W2783136423 creator A5079411695 @default.
- W2783136423 creator A5079420260 @default.
- W2783136423 creator A5089745291 @default.
- W2783136423 date "2018-01-17" @default.
- W2783136423 modified "2023-09-25" @default.
- W2783136423 title "Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner" @default.
- W2783136423 cites W1802862830 @default.
- W2783136423 cites W1841140288 @default.
- W2783136423 cites W1969396037 @default.
- W2783136423 cites W1976599392 @default.
- W2783136423 cites W1978772332 @default.
- W2783136423 cites W1982647833 @default.
- W2783136423 cites W2000901659 @default.
- W2783136423 cites W2002918915 @default.
- W2783136423 cites W2006070103 @default.
- W2783136423 cites W2006903305 @default.
- W2783136423 cites W2009441114 @default.
- W2783136423 cites W2009902514 @default.
- W2783136423 cites W2011140280 @default.
- W2783136423 cites W2011667964 @default.
- W2783136423 cites W2013342221 @default.
- W2783136423 cites W2014977126 @default.
- W2783136423 cites W2016106221 @default.
- W2783136423 cites W2020472970 @default.
- W2783136423 cites W2021226060 @default.
- W2783136423 cites W2024235590 @default.
- W2783136423 cites W2026098127 @default.
- W2783136423 cites W2028203719 @default.
- W2783136423 cites W2037150792 @default.
- W2783136423 cites W2037299745 @default.
- W2783136423 cites W2039254460 @default.
- W2783136423 cites W2051989436 @default.
- W2783136423 cites W2059519613 @default.
- W2783136423 cites W2071765776 @default.
- W2783136423 cites W2072887778 @default.
- W2783136423 cites W2094627135 @default.
- W2783136423 cites W2106912600 @default.
- W2783136423 cites W2108610727 @default.
- W2783136423 cites W2114570000 @default.
- W2783136423 cites W2132673369 @default.
- W2783136423 cites W2135632733 @default.
- W2783136423 cites W2139669573 @default.
- W2783136423 cites W2142782616 @default.
- W2783136423 cites W2160286292 @default.
- W2783136423 cites W2162418171 @default.
- W2783136423 cites W2166077025 @default.
- W2783136423 cites W2545310301 @default.
- W2783136423 doi "https://doi.org/10.1038/s41598-017-15090-5" @default.
- W2783136423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5798039" @default.
- W2783136423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29343716" @default.
- W2783136423 hasPublicationYear "2018" @default.
- W2783136423 type Work @default.
- W2783136423 sameAs 2783136423 @default.
- W2783136423 citedByCount "10" @default.
- W2783136423 countsByYear W27831364232018 @default.
- W2783136423 countsByYear W27831364232019 @default.
- W2783136423 countsByYear W27831364232020 @default.
- W2783136423 countsByYear W27831364232021 @default.
- W2783136423 crossrefType "journal-article" @default.
- W2783136423 hasAuthorship W2783136423A5010080171 @default.
- W2783136423 hasAuthorship W2783136423A5026769825 @default.
- W2783136423 hasAuthorship W2783136423A5031261105 @default.
- W2783136423 hasAuthorship W2783136423A5051266855 @default.
- W2783136423 hasAuthorship W2783136423A5067909268 @default.
- W2783136423 hasAuthorship W2783136423A5079411695 @default.
- W2783136423 hasAuthorship W2783136423A5079420260 @default.
- W2783136423 hasAuthorship W2783136423A5089745291 @default.
- W2783136423 hasBestOaLocation W27831364231 @default.
- W2783136423 hasConcept C104317684 @default.
- W2783136423 hasConcept C14036430 @default.
- W2783136423 hasConcept C2777568990 @default.
- W2783136423 hasConcept C2778813780 @default.
- W2783136423 hasConcept C2779222958 @default.
- W2783136423 hasConcept C2780912031 @default.
- W2783136423 hasConcept C515207424 @default.
- W2783136423 hasConcept C54355233 @default.
- W2783136423 hasConcept C55493867 @default.
- W2783136423 hasConcept C80315684 @default.
- W2783136423 hasConcept C86803240 @default.
- W2783136423 hasConcept C97037327 @default.
- W2783136423 hasConceptScore W2783136423C104317684 @default.
- W2783136423 hasConceptScore W2783136423C14036430 @default.
- W2783136423 hasConceptScore W2783136423C2777568990 @default.
- W2783136423 hasConceptScore W2783136423C2778813780 @default.
- W2783136423 hasConceptScore W2783136423C2779222958 @default.
- W2783136423 hasConceptScore W2783136423C2780912031 @default.
- W2783136423 hasConceptScore W2783136423C515207424 @default.
- W2783136423 hasConceptScore W2783136423C54355233 @default.
- W2783136423 hasConceptScore W2783136423C55493867 @default.
- W2783136423 hasConceptScore W2783136423C80315684 @default.
- W2783136423 hasConceptScore W2783136423C86803240 @default.
- W2783136423 hasConceptScore W2783136423C97037327 @default.
- W2783136423 hasIssue "1" @default.