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- W2783137161 abstract "During the last decade an enormous research efforthas been deployed with respect to porous materials. Design, pore size, shape,morphology and density are crucial features for increasing the surface area ofsilicone materials, aiming for a betterbiological response so cells can adhere and grow. Many medical applications utilize polydimethylsiloxane (PDMS) inmedical implants, despite its hydrophobicsurface that does not stimulate cellular adhesion. Porosity and morphology are important factors in the wettability of PDMS, but modifying the hydrophobic surface functionalization is required.To achieve this goal, the use ofcoatings with gold and silver nanoparticles or nanofilms can be used as a strategy to improve biocompatibility. This is due to the effect on mammaliancell adhesion and proliferation related to gold nanoparticles, as well as theprevention of infections related to silver nanoparticles. In this study, thepores in the silicone matrix were formed using sugar crystals as a templateagent, and later passed through a lixiviation process to form a porous siliconmatrix. Next, the matrix was placed inside acolloidal suspension; a process that allowed the immobilization of theseparticles on the surface matrix. A hybrid stable material was synthetizedthrough this process. The water absorption level of the porous silicone matrixwith and without the nanoparticles was determined. The water uptake of thematrix was higher when the nanoparticles were immobilized on the surface. Van der Waals and hydrogen bondinginteractions account for this, promoting the retention of a higherconcentration of water molecules. Higher water uptake has been identified asbeing a key factor for improving biological response, cellular adhesion andgrowth, which accelerates implant integration in the body." @default.
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- W2783137161 date "2018-01-01" @default.
- W2783137161 modified "2023-10-01" @default.
- W2783137161 title "Immobilization of Gold and Silver on a Biocompatible Porous Silicone Matrix to Obtain Hybrid Nanostructures" @default.
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- W2783137161 doi "https://doi.org/10.4236/jbnb.2018.91004" @default.
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