FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783137881> ?p ?o ?g. }

• W2783137881 abstract "As matrix metalloproteinases (MMPs), especially MMP-9 and MMP-12 are involved in the pathological processes associated with chronic obstructive pulmonary disease (COPD), we developed a novel radiofluorinated probe, 18F-IPFP, for MMPs-targeted positron emission tomography (PET). 18F-IPFP was designed by iodination of MMP inhibitor to enhance the affinity, and labelled with a compact prosthetic agent, 4-nitrophenyl 2-18F-fluoropropionate (18F-NFP). As a result, IPFP demonstrated the highest affinity toward MMP-12 (IC50 = 1.5 nM) among existing PET probes. A COPD model was employed by exposing mice to cigarette smoke and the expression levels of MMP-9 and MMP-12 were significantly increased in the lungs. Radioactivity accumulation in the lungs 90 min after administration of 18F-IPFP was 4× higher in COPD mice than normal mice, and 10× higher than in the heart, muscle, and blood. Ex vivo PET confirmed the radioactivity distribution in the tissues and autoradiography analysis demonstrated that accumulation differences in the lungs of COPD mice were 2× higher than those of normal mice. These results suggest that 18F-IPFP is a promising probe for pulmonary imaging and expected to be applied to various MMP-related diseases for early diagnosis, tracking of therapeutic effects, and new drug development in both preclinical and clinical applications." @default.
• W2783137881 created "2018-01-26" @default.
• W2783137881 creator A5006193804 @default.
• W2783137881 creator A5013962241 @default.
• W2783137881 creator A5045020127 @default.
• W2783137881 creator A5046480049 @default.
• W2783137881 creator A5047995312 @default.
• W2783137881 creator A5051857488 @default.
• W2783137881 creator A5060484739 @default.
• W2783137881 date "2018-01-22" @default.
• W2783137881 modified "2023-10-12" @default.
• W2783137881 title "Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography" @default.
• W2783137881 cites W1822096040 @default.
• W2783137881 cites W2003562328 @default.
• W2783137881 cites W2004344918 @default.
• W2783137881 cites W2040099837 @default.
• W2783137881 cites W2072649524 @default.
• W2783137881 cites W2084315800 @default.
• W2783137881 cites W2089720091 @default.
• W2783137881 cites W2096892978 @default.
• W2783137881 cites W2099776703 @default.
• W2783137881 cites W2099969611 @default.
• W2783137881 cites W2106065407 @default.
• W2783137881 cites W2113752468 @default.
• W2783137881 cites W2119767177 @default.
• W2783137881 cites W2124698558 @default.
• W2783137881 cites W2126641284 @default.
• W2783137881 cites W2127699451 @default.
• W2783137881 cites W2127951128 @default.
• W2783137881 cites W2146892597 @default.
• W2783137881 cites W2149609428 @default.
• W2783137881 cites W2153303662 @default.
• W2783137881 cites W2153523434 @default.
• W2783137881 cites W2155353529 @default.
• W2783137881 cites W2482737540 @default.
• W2783137881 cites W2542801506 @default.
• W2783137881 doi "https://doi.org/10.1038/s41598-018-19890-1" @default.
• W2783137881 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5778071" @default.
• W2783137881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29358724" @default.
• W2783137881 hasPublicationYear "2018" @default.
• W2783137881 type Work @default.
• W2783137881 sameAs 2783137881 @default.
• W2783137881 citedByCount "12" @default.
• W2783137881 countsByYear W27831378812018 @default.
• W2783137881 countsByYear W27831378812019 @default.
• W2783137881 countsByYear W27831378812020 @default.
• W2783137881 countsByYear W27831378812021 @default.
• W2783137881 countsByYear W27831378812022 @default.
• W2783137881 countsByYear W27831378812023 @default.
• W2783137881 crossrefType "journal-article" @default.
• W2783137881 hasAuthorship W2783137881A5006193804 @default.
• W2783137881 hasAuthorship W2783137881A5013962241 @default.
• W2783137881 hasAuthorship W2783137881A5045020127 @default.
• W2783137881 hasAuthorship W2783137881A5046480049 @default.
• W2783137881 hasAuthorship W2783137881A5047995312 @default.
• W2783137881 hasAuthorship W2783137881A5051857488 @default.
• W2783137881 hasAuthorship W2783137881A5060484739 @default.
• W2783137881 hasBestOaLocation W27831378811 @default.
• W2783137881 hasConcept C109523444 @default.
• W2783137881 hasConcept C126322002 @default.
• W2783137881 hasConcept C142724271 @default.
• W2783137881 hasConcept C150903083 @default.
• W2783137881 hasConcept C207001950 @default.
• W2783137881 hasConcept C26291073 @default.
• W2783137881 hasConcept C2775842073 @default.
• W2783137881 hasConcept C2775958869 @default.
• W2783137881 hasConcept C2776780178 @default.
• W2783137881 hasConcept C2776914184 @default.
• W2783137881 hasConcept C2777714996 @default.
• W2783137881 hasConcept C2989005 @default.
• W2783137881 hasConcept C2992779976 @default.
• W2783137881 hasConcept C71924100 @default.
• W2783137881 hasConcept C86803240 @default.
• W2783137881 hasConceptScore W2783137881C109523444 @default.
• W2783137881 hasConceptScore W2783137881C126322002 @default.
• W2783137881 hasConceptScore W2783137881C142724271 @default.
• W2783137881 hasConceptScore W2783137881C150903083 @default.
• W2783137881 hasConceptScore W2783137881C207001950 @default.
• W2783137881 hasConceptScore W2783137881C26291073 @default.
• W2783137881 hasConceptScore W2783137881C2775842073 @default.
• W2783137881 hasConceptScore W2783137881C2775958869 @default.
• W2783137881 hasConceptScore W2783137881C2776780178 @default.
• W2783137881 hasConceptScore W2783137881C2776914184 @default.
• W2783137881 hasConceptScore W2783137881C2777714996 @default.
• W2783137881 hasConceptScore W2783137881C2989005 @default.
• W2783137881 hasConceptScore W2783137881C2992779976 @default.
• W2783137881 hasConceptScore W2783137881C71924100 @default.
• W2783137881 hasConceptScore W2783137881C86803240 @default.
• W2783137881 hasIssue "1" @default.
• W2783137881 hasLocation W27831378811 @default.
• W2783137881 hasLocation W27831378812 @default.
• W2783137881 hasLocation W27831378813 @default.
• W2783137881 hasLocation W27831378814 @default.
• W2783137881 hasOpenAccess W2783137881 @default.
• W2783137881 hasPrimaryLocation W27831378811 @default.
• W2783137881 hasRelatedWork W1989047233 @default.
• W2783137881 hasRelatedWork W1993278796 @default.
• W2783137881 hasRelatedWork W2056756040 @default.
• W2783137881 hasRelatedWork W2159503270 @default.
• W2783137881 hasRelatedWork W2367868208 @default.

• next