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• W2783139875 abstract "// Xinheng Zhang 1, 4, 5 , Yiming Yan 1, 4 , Xiaoya Lei 1, 4 , Aijun Li 2 , Huanmin Zhang 3 , Zhenkai Dai 1, 4 , Xinjian Li 1, 4 , Weiguo Chen 1, 4, 5 , Wencheng Lin 1, 4, 5 , Feng Chen 1, 4, 5 , Jingyun Ma 1, 4, 5 and Qingmei Xie 1, 4, 5 1 College of Animal Science, South China Agricultural University and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, 510642, P. R. China 2 College of Science and Engineering, Jinan University, Guangzhou, 510632, P. R. China 3 USDA, Agriculture Research Service, Avian Disease and Oncology Laboratory, East Lansing, MI, 48823, USA 4 Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangdong, Guangzhou, 510642, P. R. China 5 South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, 510642, P. R. China Correspondence to: Qingmei Xie, email: qmx@scau.edu.cn Keywords: RNA sequencing; ALV-J; tumor; circular RNA; bioinformatics analysis Received: October 16, 2017      Accepted: December 05, 2017      Published: January 12, 2018 ABSTRACT ALV-J (subgroup J avian leucosis virus) is a kind of oncogenic exogenous retrovirus and diseases associated with ALV-J have caused severe reproduction problems in the poultry industry worldwide. However, the pathogenesis of ALV-J-induced tumor formation is still unclear. In recent years, circRNAs are validated to be related to cancer, which prompts us to explore whether aberrant expression of circRNAs exists in ALV-J-infected tumor samples. In this study, a total of 2822 differentially expressed circRNAs were detected by RNA sequencing in the tumor livers of ALV-J-susceptible chickens ( n = 3) and the normal liver samples of ALV-J-resistant chickens ( n = 3), among which 2808 circRNAs in the tumor liver samples were detected as unregulated compared to those in the normal liver samples. As circRNAs are considered as miRNA sponge, we predicted top 5 miRNA targets for 24 selected upregulated circRNAs in the ALV-J-induced tumor livers. CircRNA-miRNA-mRNA regulatory axes were also constructed to provide clear interaction relationship among them. Furthermore, Gene Ontology and KEGG pathway analyses were performed for miRNA target genes, the result of which implied that metabolism plays a key role in circRNAs alterations in ALV-J-induced tumor livers. In summary, we identified that circRNAs are involved in ALV-J-induced tumor formation in chickens. However, the pathogenicity mechanism still needs to be further explored." @default.
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• W2783139875 date "2018-01-12" @default.
• W2783139875 modified "2023-09-27" @default.
• W2783139875 title "WITHDRAWN: Identification of aberrantly expressed circRNAs in subgroup J avian leucosis virus induced tumor livers by RNA sequencing" @default.
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• W2783139875 doi "https://doi.org/10.18632/oncotarget.24181" @default.
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