FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783140071> ?p ?o ?g. }

• W2783140071 endingPage "AB92" @default.
• W2783140071 startingPage "AB92" @default.
• W2783140071 abstract "Atopic dermatitis (AD) is a chronic inflammatory skin disorder with itch as its most debilitating symptom. Blockade of the type 2 cytokines IL-4 and IL-13 with dupilumab, an anti-IL-4Rα antibody, has demonstrated unprecedented efficacy in treating AD including rapid improvements of itch. However, how disrupting type 2 cytokine signaling improves itch remains unknown. Given the remarkable effects of IL-4Rα blockade on itch, we hypothesized that, in addition to their known proinflammatory functions, IL-4 and IL-13 directly stimulate sensory neurons to mediate chronic itch. We investigated the contributions of neuronal IL-4 and IL-13 signaling to chronic itch using sensory neuron-specific genetic deletion of type 2 cytokine signaling components and pharmacologic blockade with JAK inhibitors in a mouse model of AD. We also performed observational studies to explore the anti-itch properties of JAK inhibitors in patients. We found that IL-4 and IL-13 directly activate itch-sensory neurons in mice. Strikingly, we observed that IL-4 also activates human sensory neurons, suggesting that neuronal type 2 cytokine signaling promotes itch across species. Using conditional deletion of IL-4Rα from sensory neurons, we discovered that neuronal IL-4Rα critically mediates AD-associated itch. Additionally, we found that type 2 cytokine responses in neurons were dependent on JAK1, and disruption of neuronal JAK1 signaling reduced chronic itch. Finally, in translational studies, we found that JAK inhibitors markedly improved itch symptoms in chronic itch patients. The classical immune signaling molecules IL-4Rα and JAK1 represent new targets within the sensory nervous system to treat itch in AD and other chronic itch disorders." @default.
• W2783140071 created "2018-01-26" @default.
• W2783140071 creator A5006363718 @default.
• W2783140071 creator A5008093336 @default.
• W2783140071 creator A5015320458 @default.
• W2783140071 creator A5019277323 @default.
• W2783140071 creator A5025792713 @default.
• W2783140071 creator A5032095782 @default.
• W2783140071 creator A5042551199 @default.
• W2783140071 creator A5043337949 @default.
• W2783140071 creator A5044936950 @default.
• W2783140071 creator A5048518247 @default.
• W2783140071 creator A5048604312 @default.
• W2783140071 creator A5049334882 @default.
• W2783140071 creator A5050060219 @default.
• W2783140071 creator A5053417124 @default.
• W2783140071 creator A5055055207 @default.
• W2783140071 creator A5056280633 @default.
• W2783140071 creator A5059240141 @default.
• W2783140071 creator A5060327489 @default.
• W2783140071 creator A5062711393 @default.
• W2783140071 creator A5063099787 @default.
• W2783140071 creator A5068511790 @default.
• W2783140071 creator A5071375088 @default.
• W2783140071 creator A5073099393 @default.
• W2783140071 creator A5073865035 @default.
• W2783140071 creator A5079750100 @default.
• W2783140071 creator A5080451699 @default.
• W2783140071 creator A5082705746 @default.
• W2783140071 date "2018-02-01" @default.
• W2783140071 modified "2023-10-03" @default.
• W2783140071 title "Neuronal IL-4Rα and JAK1 signaling critically mediate atopic dermatitis-associated" @default.
• W2783140071 doi "https://doi.org/10.1016/j.jaci.2017.12.294" @default.
• W2783140071 hasPublicationYear "2018" @default.
• W2783140071 type Work @default.
• W2783140071 sameAs 2783140071 @default.
• W2783140071 citedByCount "2" @default.
• W2783140071 countsByYear W27831400712019 @default.
• W2783140071 countsByYear W27831400712020 @default.
• W2783140071 crossrefType "journal-article" @default.
• W2783140071 hasAuthorship W2783140071A5006363718 @default.
• W2783140071 hasAuthorship W2783140071A5008093336 @default.
• W2783140071 hasAuthorship W2783140071A5015320458 @default.
• W2783140071 hasAuthorship W2783140071A5019277323 @default.
• W2783140071 hasAuthorship W2783140071A5025792713 @default.
• W2783140071 hasAuthorship W2783140071A5032095782 @default.
• W2783140071 hasAuthorship W2783140071A5042551199 @default.
• W2783140071 hasAuthorship W2783140071A5043337949 @default.
• W2783140071 hasAuthorship W2783140071A5044936950 @default.
• W2783140071 hasAuthorship W2783140071A5048518247 @default.
• W2783140071 hasAuthorship W2783140071A5048604312 @default.
• W2783140071 hasAuthorship W2783140071A5049334882 @default.
• W2783140071 hasAuthorship W2783140071A5050060219 @default.
• W2783140071 hasAuthorship W2783140071A5053417124 @default.
• W2783140071 hasAuthorship W2783140071A5055055207 @default.
• W2783140071 hasAuthorship W2783140071A5056280633 @default.
• W2783140071 hasAuthorship W2783140071A5059240141 @default.
• W2783140071 hasAuthorship W2783140071A5060327489 @default.
• W2783140071 hasAuthorship W2783140071A5062711393 @default.
• W2783140071 hasAuthorship W2783140071A5063099787 @default.
• W2783140071 hasAuthorship W2783140071A5068511790 @default.
• W2783140071 hasAuthorship W2783140071A5071375088 @default.
• W2783140071 hasAuthorship W2783140071A5073099393 @default.
• W2783140071 hasAuthorship W2783140071A5073865035 @default.
• W2783140071 hasAuthorship W2783140071A5079750100 @default.
• W2783140071 hasAuthorship W2783140071A5080451699 @default.
• W2783140071 hasAuthorship W2783140071A5082705746 @default.
• W2783140071 hasBestOaLocation W27831400711 @default.
• W2783140071 hasConcept C112392421 @default.
• W2783140071 hasConcept C126322002 @default.
• W2783140071 hasConcept C164027704 @default.
• W2783140071 hasConcept C169760540 @default.
• W2783140071 hasConcept C170493617 @default.
• W2783140071 hasConcept C203014093 @default.
• W2783140071 hasConcept C2776914184 @default.
• W2783140071 hasConcept C2778277574 @default.
• W2783140071 hasConcept C2778329239 @default.
• W2783140071 hasConcept C2778468042 @default.
• W2783140071 hasConcept C2778690821 @default.
• W2783140071 hasConcept C2778923194 @default.
• W2783140071 hasConcept C62478195 @default.
• W2783140071 hasConcept C71924100 @default.
• W2783140071 hasConcept C86803240 @default.
• W2783140071 hasConcept C95444343 @default.
• W2783140071 hasConceptScore W2783140071C112392421 @default.
• W2783140071 hasConceptScore W2783140071C126322002 @default.
• W2783140071 hasConceptScore W2783140071C164027704 @default.
• W2783140071 hasConceptScore W2783140071C169760540 @default.
• W2783140071 hasConceptScore W2783140071C170493617 @default.
• W2783140071 hasConceptScore W2783140071C203014093 @default.
• W2783140071 hasConceptScore W2783140071C2776914184 @default.
• W2783140071 hasConceptScore W2783140071C2778277574 @default.
• W2783140071 hasConceptScore W2783140071C2778329239 @default.
• W2783140071 hasConceptScore W2783140071C2778468042 @default.
• W2783140071 hasConceptScore W2783140071C2778690821 @default.
• W2783140071 hasConceptScore W2783140071C2778923194 @default.
• W2783140071 hasConceptScore W2783140071C62478195 @default.
• W2783140071 hasConceptScore W2783140071C71924100 @default.

• next