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- W2783141253 abstract "Abstract A simple and efficient methodology has been designed to synthesize a series of versatile and novel coumarin based scaffolds displaying several alkyl, halogen, and alkoxy groups from 4‐Bromomethylcoumarins and pre‐functionalized phenol. The title compounds have been evaluated for their in‐vitro anti‐microbial and anti‐inflammatory activity. Physiological properties like lipophilicity and IC 50 value have also been calculated. To support the in vitro results, computational experiments were carried out to analyze probable binding modes. The interactions between substituted coumarins and bovine protein showed promising activity with higher C‐score values." @default.
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- W2783141253 date "2018-01-09" @default.
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- W2783141253 title "Design, Synthesis, Biological Evaluation and Computational Study of Novel Imino-4-Aryloxymethyl-<i>2H</i> -chromen-2-one Derivatives as Potent Anti-Microbial and Antiinflammatory Agents" @default.
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- W2783141253 doi "https://doi.org/10.1002/slct.201702240" @default.
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