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- W2783142565 abstract "Objective: The aim of study was to evaluate the differential expressions of miRNAs in both sporadic and familial MS patients. Background: Multiple sclerosis (MS) is a heterogeneous disease in terms of clinical and immunological features. Although most MS cases occur sporadically, a considerable proportion of the patients are related by family. MicroRNA (miRNA)s are small non-coding RNA that mediate mRNA translation repression or mRNA degradation. miRNAs regulate translation of more than 100 genes and they could also have focused insight into diseases with heterogeneous pathogenesis, like MS. There is no study showing differences in miRNA familial versus sporadic MS in the literature. Design/Methods: This study held in Neurology Department of DEU Medical Faculty, 20 familial, 10 sporadic MS and 8 healthy controls depending on miRBase 21(http://www.mirbase.org/), total 2549 miRNA genes were screened. 2 fold changes in miRNA gene expressions were identified. Identified miRNA genes are in validation stage by Real-Time PCR experiments. Results: First findings showed that miR-5100 is increased in familial MS different from sporadic MS, while miR-432-3p is decreased. miR-451-b is increased in both groups. miR-548-aa increased in both sporadic and familial MS whereas miR-548-v increased only in sporadic MS. hsa-miR-142-3p increased in both group. Also hsa-miR-16-2-3p was increased in only familial MS. Some miRNA showed the same expressions pattern in both groups whereas some of them only increased or decreased in familial or sporadic group. Conclusions: miRNA might be useful markers for identification for differences between sporadic and familial MS. This study is a firstly showed the differential expressions of miRNA’s in familial and sporadic MS. Disclosure: Dr. Altun has nothing to disclose. Dr. Idiman has nothing to disclose. Dr. ozcelik has nothing to disclose. Dr. Kaya has nothing to disclose. Dr. TERCAN has nothing to disclose. Dr. Hasankoyoglu has nothing to disclose." @default.
- W2783142565 created "2018-01-26" @default.
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- W2783142565 date "2017-04-18" @default.
- W2783142565 modified "2023-09-26" @default.
- W2783142565 title "The differences of microRNA expressions profiles in peripheral blood cells in familial and sporadic multiple sclerosis patients (P3.383)" @default.
- W2783142565 hasPublicationYear "2017" @default.
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