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• W2783143517 endingPage "433" @default.
• W2783143517 startingPage "418" @default.
• W2783143517 abstract "T-cell immunoglobulin and mucin domain 3 (Tim-3) is a surface receptor expressed by T helper type 1 (Th1) effector CD4 T cells, which are critical for defence against intracellular pathogens and have been implicated in autoimmune disease. Previous studies showed that Tim-3 expression makes Th1 cells more susceptible to apoptosis and also marks functionally impaired T cells that arise due to chronic stimulation. However, other studies suggested that Tim-3-expressing Th1 cells do not always have these properties. To further define the relationship between Tim-3 and Th1 cell function, we analysed the characteristics of Th1 cells that expressed Tim-3 in response to brief stimulation in vitro or an acute viral infection in vivo. As expected, cultured CD4 T cells began expressing Tim-3 during Th1 differentiation and secondary stimulation generated Tim-3- and Tim-3+ fractions that were separated and further analysed. When injected into naive mice, Tim-3+ cells down-regulated Tim-3 and survived equally well compared with Tim-3- cells. Further, Tim-3- and Tim-3+ Th1 cells had similar functional responses when transferred into naive mice that were subsequently infected with lymphocytic choriomeningitis virus (LCMV). Cultured Th1 cells that expressed Tim-3 following T-cell receptor stimulation had a greater capacity to express signature Th1 cytokines than their Tim-3- counterparts and showed differential expression of genes that regulate CD4 T-cell function. Consistent with these findings, Tim-3+ Th1 cells generated in response to LCMV infection displayed augmented effector function relative to Tim-3- cells. These results suggest that Tim-3 expression by Th1 cells responding to acute stimulation can mark cells that are functionally competent and have an augmented ability to produce cytokines." @default.
• W2783143517 created "2018-01-26" @default.
• W2783143517 creator A5020687003 @default.
• W2783143517 creator A5040931929 @default.
• W2783143517 date "2018-02-08" @default.
• W2783143517 modified "2023-10-16" @default.
• W2783143517 title "Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist <i>in vivo</i> and show enhanced effector function" @default.
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• W2783143517 doi "https://doi.org/10.1111/imm.12890" @default.
• W2783143517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6002241" @default.
• W2783143517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315553" @default.
• W2783143517 hasPublicationYear "2018" @default.
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