FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783143733> ?p ?o ?g. }

• W2783143733 endingPage "18" @default.
• W2783143733 startingPage "3" @default.
• W2783143733 abstract "Identification of microRNAs (miRNAs), target genes and regulatory networks associated with innate immune and inflammatory responses and tissue damage is essential to elucidate the molecular and genetic mechanisms for resistance to mastitis. In this study, a combination of Solexa sequencing and custom miRNA chip approaches was used to profile the expression of miRNAs in bovine mammary gland at the late stage of natural infection with Staphylococcus aureus, a widespread mastitis pathogen. We found 383 loci corresponding to 277 known and 49 putative novel miRNAs, two potential mitrons and 266 differentially expressed miRNAs in the healthy and mastitic cows' mammary glands. Several interaction networks and regulators involved in mastitis susceptibility, such as ALCAM, COL1A1, APOP4, ITIH4, CRP and fibrinogen alpha (FGA), were highlighted. Significant down-regulation and location of bta-miR-26a, which targets FGA in the mastitic mammary glands, were validated using quantitative real-time PCR, in situ hybridization and dual-luciferase reporter assays. We propose that the observed miRNA variations in mammary glands of mastitic cows are related to the maintenance of immune and defense responses, cell proliferation and apoptosis, and tissue injury and healing during the late stage of infection. Furthermore, the effect of bta-miR-26a in mastitis, mediated at least in part by enhancing FGA expression, involves host defense, inflammation and tissue damage." @default.
• W2783143733 created "2018-01-26" @default.
• W2783143733 creator A5004131052 @default.
• W2783143733 creator A5014290658 @default.
• W2783143733 creator A5016770711 @default.
• W2783143733 creator A5038615774 @default.
• W2783143733 creator A5053107465 @default.
• W2783143733 creator A5058637832 @default.
• W2783143733 creator A5063783095 @default.
• W2783143733 creator A5086664284 @default.
• W2783143733 creator A5089351877 @default.
• W2783143733 date "2018-01-08" @default.
• W2783143733 modified "2023-10-15" @default.
• W2783143733 title "Solexa sequencing and custom microRNA chip reveal repertoire of microRNAs in mammary gland of bovine suffering from natural infectious mastitis" @default.
• W2783143733 cites W1742392922 @default.
• W2783143733 cites W1833918098 @default.
• W2783143733 cites W1966354069 @default.
• W2783143733 cites W1967641907 @default.
• W2783143733 cites W1970847599 @default.
• W2783143733 cites W1971234948 @default.
• W2783143733 cites W1973401140 @default.
• W2783143733 cites W1981964446 @default.
• W2783143733 cites W1991858815 @default.
• W2783143733 cites W1992650918 @default.
• W2783143733 cites W1997164591 @default.
• W2783143733 cites W1998018670 @default.
• W2783143733 cites W2005993941 @default.
• W2783143733 cites W2007542164 @default.
• W2783143733 cites W2009644747 @default.
• W2783143733 cites W2017469014 @default.
• W2783143733 cites W2020276604 @default.
• W2783143733 cites W2033518550 @default.
• W2783143733 cites W2034611409 @default.
• W2783143733 cites W2042656316 @default.
• W2783143733 cites W2045942322 @default.
• W2783143733 cites W2058906301 @default.
• W2783143733 cites W2070213312 @default.
• W2783143733 cites W2072155079 @default.
• W2783143733 cites W2084687601 @default.
• W2783143733 cites W2102122219 @default.
• W2783143733 cites W2108322090 @default.
• W2783143733 cites W2113546559 @default.
• W2783143733 cites W2118535680 @default.
• W2783143733 cites W2120738511 @default.
• W2783143733 cites W2120865735 @default.
• W2783143733 cites W2121725913 @default.
• W2783143733 cites W2123430113 @default.
• W2783143733 cites W2125945390 @default.
• W2783143733 cites W2127220612 @default.
• W2783143733 cites W2132040456 @default.
• W2783143733 cites W2132822330 @default.
• W2783143733 cites W2134304071 @default.
• W2783143733 cites W2143503237 @default.
• W2783143733 cites W2149824640 @default.
• W2783143733 cites W2150333864 @default.
• W2783143733 cites W2150712894 @default.
• W2783143733 cites W2150787212 @default.
• W2783143733 cites W2151441717 @default.
• W2783143733 cites W2152310279 @default.
• W2783143733 cites W2161527093 @default.
• W2783143733 cites W2168365587 @default.
• W2783143733 cites W2170428122 @default.
• W2783143733 cites W2621796081 @default.
• W2783143733 cites W2690746362 @default.
• W2783143733 doi "https://doi.org/10.1111/age.12628" @default.
• W2783143733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315680" @default.
• W2783143733 hasPublicationYear "2018" @default.
• W2783143733 type Work @default.
• W2783143733 sameAs 2783143733 @default.
• W2783143733 citedByCount "27" @default.
• W2783143733 countsByYear W27831437332018 @default.
• W2783143733 countsByYear W27831437332019 @default.
• W2783143733 countsByYear W27831437332020 @default.
• W2783143733 countsByYear W27831437332021 @default.
• W2783143733 countsByYear W27831437332022 @default.
• W2783143733 countsByYear W27831437332023 @default.
• W2783143733 crossrefType "journal-article" @default.
• W2783143733 hasAuthorship W2783143733A5004131052 @default.
• W2783143733 hasAuthorship W2783143733A5014290658 @default.
• W2783143733 hasAuthorship W2783143733A5016770711 @default.
• W2783143733 hasAuthorship W2783143733A5038615774 @default.
• W2783143733 hasAuthorship W2783143733A5053107465 @default.
• W2783143733 hasAuthorship W2783143733A5058637832 @default.
• W2783143733 hasAuthorship W2783143733A5063783095 @default.
• W2783143733 hasAuthorship W2783143733A5086664284 @default.
• W2783143733 hasAuthorship W2783143733A5089351877 @default.
• W2783143733 hasConcept C104317684 @default.
• W2783143733 hasConcept C121608353 @default.
• W2783143733 hasConcept C136449434 @default.
• W2783143733 hasConcept C145059251 @default.
• W2783143733 hasConcept C203014093 @default.
• W2783143733 hasConcept C2776344049 @default.
• W2783143733 hasConcept C2776914184 @default.
• W2783143733 hasConcept C2778001805 @default.
• W2783143733 hasConcept C530470458 @default.
• W2783143733 hasConcept C54355233 @default.
• W2783143733 hasConcept C86803240 @default.
• W2783143733 hasConcept C8891405 @default.

• next