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- W2783144851 abstract "Abstract RNA binding proteins (RBP) and microRNAs (miRNAs) often bind sequences in 3′ untranslated regions (UTRs) of mRNAs, and regulate stability and translation efficiency. With the identification of numerous RBPs and miRNAs, there is an urgent need for new technologies to dissect the function of the cis -acting elements of RBPs and miRNAs. We describe post-transcriptional regulatory element sequencing (PTRE-seq), a massively parallel method for assaying the target sequences of miRNAs and RBPs. We use PTRE-seq to dissect sequence preferences and interactions between miRNAs and RBPs. The binding sites for these effector molecules influenced different aspects of the RNA lifecycle: RNA stability, translation efficiency, and translation initiation. In some cases, post-transcriptional control is modular, with different factors acting independently of each other, while in other cases factors show specific epistatic interactions. The throughput, flexibility, and reproducibility of PTRE-seq make it a valuable tool to study post-transcriptional regulation by 3′UTR elements." @default.
- W2783144851 created "2018-01-26" @default.
- W2783144851 creator A5002088426 @default.
- W2783144851 creator A5024816125 @default.
- W2783144851 creator A5039532116 @default.
- W2783144851 creator A5088670558 @default.
- W2783144851 date "2018-01-19" @default.
- W2783144851 modified "2023-09-27" @default.
- W2783144851 title "PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs" @default.
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- W2783144851 doi "https://doi.org/10.1038/s41467-017-02745-0" @default.
- W2783144851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5775260" @default.
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- W2783144851 hasPublicationYear "2018" @default.
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