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- W2783144947 abstract "In nature, the maximal growth rates vary widely among different bacteria species. Fast-growing bacteria species such as Escherichia coli can have a shortest generation time of 20 min. Slow-growing bacteria species are perhaps best known for Mycobacterium tuberculosis, a human pathogen with a generation time being no less than 16 h. Despite of the significant progress made on understanding the pathogenesis of M. tuberculosis, we know little on the origin of its intriguingly slow growth. From a global view, the intrinsic constraint of the maximal growth rate of bacteria remains to be a fundamental question in microbiology. In this review, we analyze and discuss this issue from the angle of protein translation capacity, which is the major demand for cell growth. Based on quantitative analysis, we propose four parameters: rRNA chain elongation rate, abundance of RNA polymerase engaged in rRNA synthesis, polypeptide chain elongation rate, and active ribosome fraction, which potentially limit the maximal growth rate of bacteria. We further discuss the relation of these parameters with the growth rate for M. tuberculosis as well as other bacterial species. We highlight future comprehensive investigation of these parameters for different bacteria species to understand how bacteria set their own specific growth rates." @default.
- W2783144947 created "2018-01-26" @default.
- W2783144947 creator A5014680969 @default.
- W2783144947 creator A5072782471 @default.
- W2783144947 date "2018-01-15" @default.
- W2783144947 modified "2023-10-16" @default.
- W2783144947 title "On the intrinsic constraint of bacterial growth rate:<i>M. tuberculosis</i>’s view of the protein translation capacity" @default.
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- W2783144947 doi "https://doi.org/10.1080/1040841x.2018.1425672" @default.
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