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• W2783146396 abstract "The potent cytotoxicity and unique mode of action make the enediyne antitumor antibiotic C-1027 an exquisite drug candidate for anticancer chemotherapy. However, clinical development of C-1027 has been hampered by its low titer from the original producer Streptomyces globisporus C-1027. Here we report three new C-1027 alternative producers, Streptomyces sp. CB00657, CB02329, and CB03608, from The Scripps Research Institute actinomycetes strain collection. Together with the previously disclosed Streptomyces sp. CB02366 strain, four C-1027 alternative producers with C-1027 titers of up to 11-fold higher than the original producer have been discovered. The five C-1027 producers, isolated from distant geographic locations, are distinct Streptomyces strains based on morphology and taxonomy. Pulsed-field gel electrophoresis and Southern analysis of the five C-1027 producers reveal that their C-1027 biosynthetic gene clusters (BGCs) are all located on giant plasmids of varying sizes. The high nucleotide sequence similarity among the five C-1027 BGCs implies that they most likely have evolved from a common ancestor." @default.
• W2783146396 created "2018-01-26" @default.
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• W2783146396 date "2018-01-18" @default.
• W2783146396 modified "2023-10-05" @default.
• W2783146396 title "Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers" @default.
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• W2783146396 doi "https://doi.org/10.1021/acs.jnatprod.7b01013" @default.
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