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- W2783147384 abstract "Accumulating evidence supports a relationship between the complexity and diversity of the gut microbiota and host diseases. In addition to alterations in the gut microbial composition, the metabolic potential of gut microbiota has been identified as a contributing factor in the development of diseases. Recent technological developments of molecular and biochemical analyses enable us to detect and characterize the gut microbiota via assessment and classification of its genomes and corresponding metabolites. These advances have provided emerging data supporting the role of gut microbiota in various physiological activities including host metabolism, neurological development, energy homeostasis, and immune regulation. Although few human studies have looked into the causative associations and underlying pathophysiology of the gut microbiota and host disease, a growing body of preclinical and clinical evidence supports the theory that the gut microbiota and its metabolites have the potential to be a novel therapeutic and preventative target for cardiovascular and metabolic diseases. In this review, we highlight the interplay between the gut microbiota and its metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease." @default.
- W2783147384 created "2018-01-26" @default.
- W2783147384 creator A5035023430 @default.
- W2783147384 creator A5090892101 @default.
- W2783147384 date "2018-01-11" @default.
- W2783147384 modified "2023-09-25" @default.
- W2783147384 title "Gut microbiota in cardiovascular disease and heart failure" @default.
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- W2783147384 doi "https://doi.org/10.1042/cs20171090" @default.
- W2783147384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413501" @default.
- W2783147384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29326279" @default.
- W2783147384 hasPublicationYear "2018" @default.
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