FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783149164> ?p ?o ?g. }

• W2783149164 abstract "Abstract Complex proteoforms contain various primary structural alterations resulting from variations in genes, RNA, and proteins. Top‐down mass spectrometry is commonly used for analyzing complex proteoforms because it provides whole sequence information of the proteoforms. Proteoform identification by top‐down mass spectral database search is a challenging computational problem because the types and/or locations of some alterations in target proteoforms are in general unknown. Although spectral alignment and mass graph alignment algorithms have been proposed for identifying proteoforms with unknown alterations, they are extremely slow to align millions of spectra against tens of thousands of protein sequences in high throughput proteome level analyses. Many software tools in this area combine efficient protein sequence filtering algorithms and spectral alignment algorithms to speed up database search. As a result, the performance of these tools heavily relies on the sensitivity and efficiency of their filtering algorithms. Here, we propose two efficient approximate spectrum‐based filtering algorithms for proteoform identification. We evaluated the performances of the proposed algorithms and four existing ones on simulated and real top‐down mass spectrometry data sets. Experiments showed that the proposed algorithms outperformed the existing ones for complex proteoform identification. In addition, combining the proposed filtering algorithms and mass graph alignment algorithms identified many proteoforms missed by ProSightPC in proteome‐level proteoform analyses." @default.
• W2783149164 created "2018-01-26" @default.
• W2783149164 creator A5030727063 @default.
• W2783149164 creator A5074292548 @default.
• W2783149164 creator A5090843413 @default.
• W2783149164 date "2018-02-01" @default.
• W2783149164 modified "2023-09-26" @default.
• W2783149164 title "Systematic Evaluation of Protein Sequence Filtering Algorithms for Proteoform Identification Using Top-Down Mass Spectrometry" @default.
• W2783149164 cites W1480858518 @default.
• W2783149164 cites W1512708776 @default.
• W2783149164 cites W1519955500 @default.
• W2783149164 cites W1568341953 @default.
• W2783149164 cites W1577446317 @default.
• W2783149164 cites W1966557933 @default.
• W2783149164 cites W1970917421 @default.
• W2783149164 cites W1993428821 @default.
• W2783149164 cites W2006750707 @default.
• W2783149164 cites W2007550555 @default.
• W2783149164 cites W2015392253 @default.
• W2783149164 cites W2019301043 @default.
• W2783149164 cites W2025955263 @default.
• W2783149164 cites W2041230108 @default.
• W2783149164 cites W2043828494 @default.
• W2783149164 cites W2045985536 @default.
• W2783149164 cites W2054667035 @default.
• W2783149164 cites W2058135122 @default.
• W2783149164 cites W2060373419 @default.
• W2783149164 cites W2070948666 @default.
• W2783149164 cites W2075036506 @default.
• W2783149164 cites W2095826175 @default.
• W2783149164 cites W2099088617 @default.
• W2783149164 cites W2106309221 @default.
• W2783149164 cites W2109948527 @default.
• W2783149164 cites W2110438218 @default.
• W2783149164 cites W2115007450 @default.
• W2783149164 cites W2117262948 @default.
• W2783149164 cites W2124358769 @default.
• W2783149164 cites W2126139276 @default.
• W2783149164 cites W2131381861 @default.
• W2783149164 cites W2145907583 @default.
• W2783149164 cites W2146482199 @default.
• W2783149164 cites W2147354890 @default.
• W2783149164 cites W2149591661 @default.
• W2783149164 cites W2151188405 @default.
• W2783149164 cites W2155843164 @default.
• W2783149164 cites W2171192777 @default.
• W2783149164 cites W2175428996 @default.
• W2783149164 cites W2179083672 @default.
• W2783149164 cites W2286617058 @default.
• W2783149164 cites W2289907074 @default.
• W2783149164 cites W2462197865 @default.
• W2783149164 cites W2562897054 @default.
• W2783149164 cites W2607310450 @default.
• W2783149164 cites W2739999456 @default.
• W2783149164 cites W2743289556 @default.
• W2783149164 doi "https://doi.org/10.1002/pmic.201700306" @default.
• W2783149164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5825287" @default.
• W2783149164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29327814" @default.
• W2783149164 hasPublicationYear "2018" @default.
• W2783149164 type Work @default.
• W2783149164 sameAs 2783149164 @default.
• W2783149164 citedByCount "10" @default.
• W2783149164 countsByYear W27831491642018 @default.
• W2783149164 countsByYear W27831491642019 @default.
• W2783149164 countsByYear W27831491642020 @default.
• W2783149164 countsByYear W27831491642021 @default.
• W2783149164 crossrefType "journal-article" @default.
• W2783149164 hasAuthorship W2783149164A5030727063 @default.
• W2783149164 hasAuthorship W2783149164A5074292548 @default.
• W2783149164 hasAuthorship W2783149164A5090843413 @default.
• W2783149164 hasBestOaLocation W27831491642 @default.
• W2783149164 hasConcept C104317684 @default.
• W2783149164 hasConcept C104397665 @default.
• W2783149164 hasConcept C11413529 @default.
• W2783149164 hasConcept C116834253 @default.
• W2783149164 hasConcept C124101348 @default.
• W2783149164 hasConcept C132525143 @default.
• W2783149164 hasConcept C162356407 @default.
• W2783149164 hasConcept C185592680 @default.
• W2783149164 hasConcept C41008148 @default.
• W2783149164 hasConcept C41584329 @default.
• W2783149164 hasConcept C43617362 @default.
• W2783149164 hasConcept C55493867 @default.
• W2783149164 hasConcept C59822182 @default.
• W2783149164 hasConcept C60644358 @default.
• W2783149164 hasConcept C80444323 @default.
• W2783149164 hasConcept C86803240 @default.
• W2783149164 hasConceptScore W2783149164C104317684 @default.
• W2783149164 hasConceptScore W2783149164C104397665 @default.
• W2783149164 hasConceptScore W2783149164C11413529 @default.
• W2783149164 hasConceptScore W2783149164C116834253 @default.
• W2783149164 hasConceptScore W2783149164C124101348 @default.
• W2783149164 hasConceptScore W2783149164C132525143 @default.
• W2783149164 hasConceptScore W2783149164C162356407 @default.
• W2783149164 hasConceptScore W2783149164C185592680 @default.
• W2783149164 hasConceptScore W2783149164C41008148 @default.
• W2783149164 hasConceptScore W2783149164C41584329 @default.
• W2783149164 hasConceptScore W2783149164C43617362 @default.
• W2783149164 hasConceptScore W2783149164C55493867 @default.
• W2783149164 hasConceptScore W2783149164C59822182 @default.

• next