Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783151045> ?p ?o ?g. }
- W2783151045 endingPage "172" @default.
- W2783151045 startingPage "159" @default.
- W2783151045 abstract "The acquisition of biallelic mutations in the APC gene is a rate-limiting step in the development of most colorectal cancers and occurs in the earliest lesions. APC encodes a 312-kDa protein that localizes to multiple subcellular compartments and performs diverse functions. APC participates in a cytoplasmic complex that promotes the destruction of the transcriptional licensing factor β-catenin; APC mutations that abolish this function trigger constitutive activation of the canonical WNT signaling pathway, a characteristic found in almost all colorectal cancers. By negatively regulating canonical WNT signaling, APC counteracts proliferation, promotes differentiation, facilitates apoptosis, and suppresses invasion and tumor progression. APC further antagonizes canonical WNT signaling by interacting with and counteracting β-catenin in the nucleus. APC also suppresses tumor initiation and progression in the colorectal epithelium through functions that are independent of canonical WNT signaling. APC regulates the mitotic spindle to facilitate proper chromosome segregation, localizes to the cell periphery and cell protrusions to establish cell polarity and appropriate directional migration, and inhibits DNA replication by interacting directly with DNA. Mutations in APC are often frameshifts, insertions, or deletions that introduce premature stop codons and lead to the production of truncated APC proteins that lack its normal functions and possess tumorigenic properties. Therapeutic approaches in development for the treatment of APC-deficient tumors are focused on the inhibition of canonical WNT signaling, especially through targets downstream of APC in the pathway, or on the restoration of wild-type APC expression." @default.
- W2783151045 created "2018-01-26" @default.
- W2783151045 creator A5009455182 @default.
- W2783151045 creator A5061124226 @default.
- W2783151045 creator A5088753285 @default.
- W2783151045 date "2018-01-09" @default.
- W2783151045 modified "2023-10-09" @default.
- W2783151045 title "Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting" @default.
- W2783151045 cites W1484025944 @default.
- W2783151045 cites W1507944948 @default.
- W2783151045 cites W1544046482 @default.
- W2783151045 cites W1546492519 @default.
- W2783151045 cites W1554815317 @default.
- W2783151045 cites W1583352928 @default.
- W2783151045 cites W1655178001 @default.
- W2783151045 cites W1663072708 @default.
- W2783151045 cites W1666932156 @default.
- W2783151045 cites W1809606297 @default.
- W2783151045 cites W182823762 @default.
- W2783151045 cites W1900557155 @default.
- W2783151045 cites W1920794749 @default.
- W2783151045 cites W1964311602 @default.
- W2783151045 cites W1964739066 @default.
- W2783151045 cites W1966121721 @default.
- W2783151045 cites W1967137553 @default.
- W2783151045 cites W1967243795 @default.
- W2783151045 cites W1967921405 @default.
- W2783151045 cites W1969959095 @default.
- W2783151045 cites W1975993620 @default.
- W2783151045 cites W1978713117 @default.
- W2783151045 cites W1979056927 @default.
- W2783151045 cites W1979618971 @default.
- W2783151045 cites W1980620631 @default.
- W2783151045 cites W1981498981 @default.
- W2783151045 cites W1982603620 @default.
- W2783151045 cites W1983567075 @default.
- W2783151045 cites W1985184859 @default.
- W2783151045 cites W1988136514 @default.
- W2783151045 cites W1989215255 @default.
- W2783151045 cites W1992271049 @default.
- W2783151045 cites W1992595726 @default.
- W2783151045 cites W1994029539 @default.
- W2783151045 cites W1995660054 @default.
- W2783151045 cites W1996982933 @default.
- W2783151045 cites W1998170462 @default.
- W2783151045 cites W1999982684 @default.
- W2783151045 cites W2002404925 @default.
- W2783151045 cites W2003927439 @default.
- W2783151045 cites W2005088732 @default.
- W2783151045 cites W2008557163 @default.
- W2783151045 cites W2012039807 @default.
- W2783151045 cites W2014460650 @default.
- W2783151045 cites W2014583973 @default.
- W2783151045 cites W2014995450 @default.
- W2783151045 cites W2015941534 @default.
- W2783151045 cites W2016634986 @default.
- W2783151045 cites W2018194912 @default.
- W2783151045 cites W2018348035 @default.
- W2783151045 cites W2018516624 @default.
- W2783151045 cites W2023649138 @default.
- W2783151045 cites W2026901159 @default.
- W2783151045 cites W2027864149 @default.
- W2783151045 cites W2032355637 @default.
- W2783151045 cites W2033126020 @default.
- W2783151045 cites W2034373020 @default.
- W2783151045 cites W2035192365 @default.
- W2783151045 cites W2035780143 @default.
- W2783151045 cites W2036397188 @default.
- W2783151045 cites W2036811006 @default.
- W2783151045 cites W2036885749 @default.
- W2783151045 cites W2038498488 @default.
- W2783151045 cites W2039661491 @default.
- W2783151045 cites W2039797518 @default.
- W2783151045 cites W2040942754 @default.
- W2783151045 cites W2048716652 @default.
- W2783151045 cites W2050750704 @default.
- W2783151045 cites W2051751077 @default.
- W2783151045 cites W2052581434 @default.
- W2783151045 cites W2052690509 @default.
- W2783151045 cites W2053029064 @default.
- W2783151045 cites W2053950147 @default.
- W2783151045 cites W2055349636 @default.
- W2783151045 cites W2057210535 @default.
- W2783151045 cites W2057257265 @default.
- W2783151045 cites W2058194940 @default.
- W2783151045 cites W2059354353 @default.
- W2783151045 cites W2059813946 @default.
- W2783151045 cites W2060998383 @default.
- W2783151045 cites W2066362124 @default.
- W2783151045 cites W2067526109 @default.
- W2783151045 cites W2068142269 @default.
- W2783151045 cites W2069561137 @default.
- W2783151045 cites W2069750786 @default.
- W2783151045 cites W2071506358 @default.
- W2783151045 cites W2078576765 @default.
- W2783151045 cites W2078591745 @default.
- W2783151045 cites W2079883750 @default.
- W2783151045 cites W2080480789 @default.