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• W2783152327 abstract "Objective. To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD). Methods. We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7). Results. Anakinra resulted in complete or partial remission in 3/10 and 5/10 patients, respectively, and no efficacy in 2/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3/7 and 4/7 patients, respectively. Conclusion. These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment." @default.
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• W2783152327 date "2018-01-15" @default.
• W2783152327 modified "2023-10-14" @default.
• W2783152327 title "Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review" @default.
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• W2783152327 doi "https://doi.org/10.3899/jrheum.170684" @default.
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