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- W2783155489 abstract "Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium-a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium-responsive lipid switch 1, designed to undergo conformational changes upon calcium binding. The conformational change perturbs membrane integrity, thereby promoting cargo release. This was shown through fluorescence-based release assays via dose-dependent response depending on the percentage of 1 in liposomes, with minimal background leakage in controls. DLS experiments indicated dramatic changes in particle size upon treatment of liposomes containing 1 with calcium. In a comparison of ten naturally occurring metal cations, calcium provided the greatest release. Finally, STEM images showed significant changes in liposome morphology upon treatment of liposomes containing 1 with calcium. These results showcase lipid switches driven by molecular recognition principles as an exciting avenue for controlling membrane properties." @default.
- W2783155489 created "2018-01-26" @default.
- W2783155489 creator A5007715609 @default.
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- W2783155489 date "2018-02-08" @default.
- W2783155489 modified "2023-09-23" @default.
- W2783155489 title "Calcium-Responsive Liposomes via a Synthetic Lipid Switch" @default.
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- W2783155489 doi "https://doi.org/10.1002/chem.201705810" @default.
- W2783155489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29323763" @default.
- W2783155489 hasPublicationYear "2018" @default.
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