Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783158618> ?p ?o ?g. }
- W2783158618 abstract "Abstract Aspergillus fumigatus and multiple other Aspergillus species cause a wide range of lung infections, collectively termed aspergillosis. Aspergilli are ubiquitous in environment with healthy immune systems routinely eliminating inhaled conidia, however, Aspergilli can become an opportunistic pathogen in immune-compromised patients. The aspergillosis mortality rate and emergence of drug-resistance reveals an urgent need to identify novel targets. Secreted and cell membrane proteins play a critical role in fungal-host interactions and pathogenesis. Using a computational pipeline integrating data from high-throughput experiments and bioinformatic predictions, we have identified secreted and cell membrane proteins in ten Aspergillus species known to cause aspergillosis. Small secreted and effector-like proteins similar to agents of fungal-plant pathogenesis were also identified within each secretome. A comparison with humans revealed that at least 70% of Aspergillus secretomes has no sequence similarity with the human proteome. An analysis of antigenic qualities of Aspergillus proteins revealed that the secretome is significantly more antigenic than cell membrane proteins or the complete proteome. Finally, overlaying an expression dataset, four A. fumigatus proteins upregulated during infection and with available structures, were found to be structurally similar to known drug target proteins in other organisms, and were able to dock in silico with the respective drug." @default.
- W2783158618 created "2018-01-26" @default.
- W2783158618 creator A5004017157 @default.
- W2783158618 creator A5004663237 @default.
- W2783158618 creator A5005790892 @default.
- W2783158618 creator A5031877647 @default.
- W2783158618 creator A5070841403 @default.
- W2783158618 creator A5077842292 @default.
- W2783158618 date "2017-12-08" @default.
- W2783158618 modified "2023-09-28" @default.
- W2783158618 title "Comparative systems analysis of the secretome of the opportunistic pathogen Aspergillus fumigatus and other Aspergillus species" @default.
- W2783158618 cites W1495164740 @default.
- W2783158618 cites W1537641994 @default.
- W2783158618 cites W1572283658 @default.
- W2783158618 cites W1680981672 @default.
- W2783158618 cites W1944240623 @default.
- W2783158618 cites W1965287301 @default.
- W2783158618 cites W1966699480 @default.
- W2783158618 cites W1972912205 @default.
- W2783158618 cites W1976325156 @default.
- W2783158618 cites W1979653427 @default.
- W2783158618 cites W1996273753 @default.
- W2783158618 cites W1996423252 @default.
- W2783158618 cites W2010465683 @default.
- W2783158618 cites W2012746420 @default.
- W2783158618 cites W2017763864 @default.
- W2783158618 cites W2018518196 @default.
- W2783158618 cites W2024645073 @default.
- W2783158618 cites W2033452345 @default.
- W2783158618 cites W2034883412 @default.
- W2783158618 cites W2034911186 @default.
- W2783158618 cites W2042420688 @default.
- W2783158618 cites W2045262925 @default.
- W2783158618 cites W2046819854 @default.
- W2783158618 cites W2047552654 @default.
- W2783158618 cites W2047605881 @default.
- W2783158618 cites W2048277394 @default.
- W2783158618 cites W2052375196 @default.
- W2783158618 cites W2052503528 @default.
- W2783158618 cites W2054332073 @default.
- W2783158618 cites W2056555131 @default.
- W2783158618 cites W2060761604 @default.
- W2783158618 cites W2061198209 @default.
- W2783158618 cites W2061285160 @default.
- W2783158618 cites W2061443212 @default.
- W2783158618 cites W2062946300 @default.
- W2783158618 cites W2063064049 @default.
- W2783158618 cites W2066609648 @default.
- W2783158618 cites W2068156301 @default.
- W2783158618 cites W2072238962 @default.
- W2783158618 cites W2077065650 @default.
- W2783158618 cites W2079928619 @default.
- W2783158618 cites W2081513270 @default.
- W2783158618 cites W2083998535 @default.
- W2783158618 cites W2085469206 @default.
- W2783158618 cites W2090677789 @default.
- W2783158618 cites W2092921819 @default.
- W2783158618 cites W2094201044 @default.
- W2783158618 cites W2096728005 @default.
- W2783158618 cites W2099769947 @default.
- W2783158618 cites W2099946731 @default.
- W2783158618 cites W2101291993 @default.
- W2783158618 cites W2102182346 @default.
- W2783158618 cites W2102245393 @default.
- W2783158618 cites W2103539617 @default.
- W2783158618 cites W2104269722 @default.
- W2783158618 cites W2104634369 @default.
- W2783158618 cites W2105668062 @default.
- W2783158618 cites W2105909024 @default.
- W2783158618 cites W2106383137 @default.
- W2783158618 cites W2107106627 @default.
- W2783158618 cites W2107158607 @default.
- W2783158618 cites W2109006822 @default.
- W2783158618 cites W2111105704 @default.
- W2783158618 cites W2112399027 @default.
- W2783158618 cites W2115318565 @default.
- W2783158618 cites W2115933717 @default.
- W2783158618 cites W2120814389 @default.
- W2783158618 cites W2120846084 @default.
- W2783158618 cites W2121353031 @default.
- W2783158618 cites W2121962352 @default.
- W2783158618 cites W2122559203 @default.
- W2783158618 cites W2123440974 @default.
- W2783158618 cites W2124088653 @default.
- W2783158618 cites W2124431373 @default.
- W2783158618 cites W2124551605 @default.
- W2783158618 cites W2126201929 @default.
- W2783158618 cites W2127879121 @default.
- W2783158618 cites W2130479394 @default.
- W2783158618 cites W2131778095 @default.
- W2783158618 cites W2134758330 @default.
- W2783158618 cites W2134967712 @default.
- W2783158618 cites W2140952049 @default.
- W2783158618 cites W2141197648 @default.
- W2783158618 cites W2141816565 @default.
- W2783158618 cites W2152458080 @default.
- W2783158618 cites W2152770371 @default.
- W2783158618 cites W2155241004 @default.
- W2783158618 cites W2157646868 @default.
- W2783158618 cites W2158173168 @default.