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- W2783160163 abstract "Salmonella Typhi is the cause of typhoid fever, a major global health concern. An essential virulence factor of this pathogen is typhoid toxin. In contrast to most AB-type toxins, typhoid toxin is exclusively expressed by intracellular bacteria. The regulatory networks that ensure this unique gene expression pattern are unknown. Here, we developed FAST-INSeq, a genome-wide screening approach to identify S. Typhi genes required for typhoid toxin expression within infected cells. We find that typhoid toxin expression is controlled by a silencing and counter-silencing mechanism through the opposing actions of the PhoP/PhoQ two-component regulatory system and the histone-like protein H-NS. The screen also identified bacterial mutants that alter the proportion of intracellular S. Typhi that reside within an intravacuolar environment, which was essential for toxin expression. Collectively, these data describe a regulatory mechanism that allows a bacterial pathogen to exclusively express a virulence factor when located within a specific intracellular compartment." @default.
- W2783160163 created "2018-01-26" @default.
- W2783160163 creator A5016995233 @default.
- W2783160163 creator A5055561923 @default.
- W2783160163 date "2018-01-01" @default.
- W2783160163 modified "2023-10-12" @default.
- W2783160163 title "Decoding a Salmonella Typhi Regulatory Network that Controls Typhoid Toxin Expression within Human Cells" @default.
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- W2783160163 doi "https://doi.org/10.1016/j.chom.2017.12.001" @default.
- W2783160163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5789772" @default.
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