FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783160231> ?p ?o ?g. }

• W2783160231 endingPage "1663" @default.
• W2783160231 startingPage "1599" @default.
• W2783160231 abstract "Rapid progress in genome sequencing technology has put us firmly into a postgenomic era. A key challenge in biomedical research is harnessing genome sequence to fulfill the promise of personalized medicine. This Review describes how genome sequencing has enabled the identification of disease-causing biomolecules and how these data have been converted into chemical probes of function, preclinical lead modalities, and ultimately U.S. Food and Drug Administration (FDA)-approved drugs. In particular, we focus on the use of oligonucleotide-based modalities to target disease-causing RNAs; small molecules that target DNA, RNA, or protein; the rational repurposing of known therapeutic modalities; and the advantages of pharmacogenetics. Lastly, we discuss the remaining challenges and opportunities in the direct utilization of genome sequence to enable design of medicines." @default.
• W2783160231 created "2018-01-26" @default.
• W2783160231 creator A5017275370 @default.
• W2783160231 creator A5031039104 @default.
• W2783160231 creator A5040427690 @default.
• W2783160231 creator A5042677350 @default.
• W2783160231 creator A5067018456 @default.
• W2783160231 creator A5080126683 @default.
• W2783160231 date "2018-01-11" @default.
• W2783160231 modified "2023-10-08" @default.
• W2783160231 title "Using Genome Sequence to Enable the Design of Medicines and Chemical Probes" @default.
• W2783160231 cites W114839291 @default.
• W2783160231 cites W1221250553 @default.
• W2783160231 cites W125796121 @default.
• W2783160231 cites W142058135 @default.
• W2783160231 cites W1438161774 @default.
• W2783160231 cites W144343646 @default.
• W2783160231 cites W144423133 @default.
• W2783160231 cites W1450574606 @default.
• W2783160231 cites W1481978003 @default.
• W2783160231 cites W1486369891 @default.
• W2783160231 cites W1490650258 @default.
• W2783160231 cites W1496719976 @default.
• W2783160231 cites W1500728559 @default.
• W2783160231 cites W1515782956 @default.
• W2783160231 cites W1517723618 @default.
• W2783160231 cites W1523125680 @default.
• W2783160231 cites W1523413020 @default.
• W2783160231 cites W1525091092 @default.
• W2783160231 cites W1530482967 @default.
• W2783160231 cites W1532331378 @default.
• W2783160231 cites W1533447420 @default.
• W2783160231 cites W1537784070 @default.
• W2783160231 cites W1539571840 @default.
• W2783160231 cites W1545334093 @default.
• W2783160231 cites W1556323918 @default.
• W2783160231 cites W1585769092 @default.
• W2783160231 cites W1585894933 @default.
• W2783160231 cites W1586243412 @default.
• W2783160231 cites W1589654967 @default.
• W2783160231 cites W1605148759 @default.
• W2783160231 cites W1611419331 @default.
• W2783160231 cites W1640318440 @default.
• W2783160231 cites W1647075334 @default.
• W2783160231 cites W1749022239 @default.
• W2783160231 cites W1779286308 @default.
• W2783160231 cites W1780086376 @default.
• W2783160231 cites W1788240279 @default.
• W2783160231 cites W1796096082 @default.
• W2783160231 cites W1797572428 @default.
• W2783160231 cites W1802218256 @default.
• W2783160231 cites W1822869875 @default.
• W2783160231 cites W1832285227 @default.
• W2783160231 cites W1838685504 @default.
• W2783160231 cites W1868158647 @default.
• W2783160231 cites W1868355974 @default.
• W2783160231 cites W1871235281 @default.
• W2783160231 cites W1873092316 @default.
• W2783160231 cites W1890902147 @default.
• W2783160231 cites W1892175722 @default.
• W2783160231 cites W1896195310 @default.
• W2783160231 cites W1906809867 @default.
• W2783160231 cites W1913218312 @default.
• W2783160231 cites W1916491745 @default.
• W2783160231 cites W1920303762 @default.
• W2783160231 cites W1927051535 @default.
• W2783160231 cites W1928092242 @default.
• W2783160231 cites W1940241680 @default.
• W2783160231 cites W1950677051 @default.
• W2783160231 cites W1952507411 @default.
• W2783160231 cites W1955899532 @default.
• W2783160231 cites W1956352222 @default.
• W2783160231 cites W1958284284 @default.
• W2783160231 cites W1964037695 @default.
• W2783160231 cites W1964164090 @default.
• W2783160231 cites W1964858690 @default.
• W2783160231 cites W1964916610 @default.
• W2783160231 cites W1965277435 @default.
• W2783160231 cites W1965306643 @default.
• W2783160231 cites W1967120946 @default.
• W2783160231 cites W1967833179 @default.
• W2783160231 cites W1968282235 @default.
• W2783160231 cites W1968614822 @default.
• W2783160231 cites W1968949098 @default.
• W2783160231 cites W1969444407 @default.
• W2783160231 cites W1969697265 @default.
• W2783160231 cites W1969757078 @default.
• W2783160231 cites W1970822548 @default.
• W2783160231 cites W1971015083 @default.
• W2783160231 cites W1971267920 @default.
• W2783160231 cites W1971625140 @default.
• W2783160231 cites W1971775892 @default.
• W2783160231 cites W1971946342 @default.
• W2783160231 cites W1972659204 @default.
• W2783160231 cites W1973034078 @default.
• W2783160231 cites W1973352434 @default.
• W2783160231 cites W1973421470 @default.
• W2783160231 cites W1973555911 @default.

• next