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• W2783160351 abstract "Abstract Changes in temperature, ionic strength or electrical field are generally employed to dehybridize double‐stranded DNA (dsDNA). In contrast, we propose potential‐induced dsDNA dehybridization to distinguish fully matched target DNA (tDNA) from tDNA with a single nucleotide polymorphism (SNP) by following their dehybridization kinetics through in situ surface enhanced Raman scattering (SERS). The determination of the potential that evokes notable dehybridization of dsDNA without causing any desorption of the immobilized probe DNA (pDNA) from the electrode surface was performed by investigating the desorption kinetics of labelled single‐stranded DNA (ssDNA) and dehybridization kinetics of dsDNA with labelled tDNA. This comparatively simple approach allows for SNP detection within minutes." @default.
• W2783160351 created "2018-01-26" @default.
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• W2783160351 date "2018-01-19" @default.
• W2783160351 modified "2023-10-17" @default.
• W2783160351 title "Monitoring Potential-Induced DNA Dehybridization Kinetics for Single Nucleotide Polymorphism Detection by using In Situ Surface Enhanced Raman Scattering" @default.
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• W2783160351 doi "https://doi.org/10.1002/celc.201701220" @default.
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