FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783160856> ?p ?o ?g. }

• W2783160856 endingPage "1062" @default.
• W2783160856 startingPage "1049" @default.
• W2783160856 abstract "Export Generation of de novo donor-specific antibodies (dnDSAs) after renal transplant is recognized as the leading cause of late transplant failure. Hence, the optimal immunosuppressive strategies to limit dnDSA development need to be defined. Recent clinical trials using the novel costimulatory blockade agent CTLA4-Ig (Belatacept) have shown that kidney transplant recipients (KTRs) treated with Belatacept have better graft survival and function and a lower proportion of dnDSAs than control-treated KTRs. Mechanisms involved in the control of humoral responses by Belatacept remain to be investigated. Here, we analyzed the effect of Belatacept on different steps of the B cell–mediated response in humans. In vitro, Belatacept reduced plasmablast differentiation, Ig production, and the expression of the major transcription factor involved in plasma cell function, Blimp-1, in a T cell–independent manner. Moreover, Belatacept induced activation of the STAT3 transcription factor in stimulated B cells and reduced the expression of CD86. Additionally, Belatacept blocked CD28-mediated activation of T follicular helper cells (Tfhs) in an autologous Tfh-memory B cells model. We then validated these observations in KTRs treated with Belatacept, who had a reduced proportion of blood effector B cells and activated Tfh (PD1+ICOS+) compared with control-treated KTRs. Our in vitro and in vivo results suggest that Belatacept modulates B cell function directly and at the level of B cell-Tfh interaction. These mechanisms likely account for the optimal control of humoral responses observed in KTRs treated with Belatacept." @default.
• W2783160856 created "2018-01-26" @default.
• W2783160856 creator A5000254733 @default.
• W2783160856 creator A5012996331 @default.
• W2783160856 creator A5024389042 @default.
• W2783160856 creator A5031884367 @default.
• W2783160856 creator A5032721048 @default.
• W2783160856 creator A5035690548 @default.
• W2783160856 creator A5047785825 @default.
• W2783160856 creator A5051102653 @default.
• W2783160856 creator A5056227490 @default.
• W2783160856 creator A5072931338 @default.
• W2783160856 date "2018-01-10" @default.
• W2783160856 modified "2023-10-13" @default.
• W2783160856 title "Control of Humoral Response in Renal Transplantation by Belatacept Depends on a Direct Effect on B Cells and Impaired T Follicular Helper-B Cell Crosstalk" @default.
• W2783160856 cites W1486598251 @default.
• W2783160856 cites W1535248058 @default.
• W2783160856 cites W1547450219 @default.
• W2783160856 cites W1554010547 @default.
• W2783160856 cites W1554670304 @default.
• W2783160856 cites W1643642339 @default.
• W2783160856 cites W1823237391 @default.
• W2783160856 cites W1831873206 @default.
• W2783160856 cites W1914370328 @default.
• W2783160856 cites W1922868692 @default.
• W2783160856 cites W1986141384 @default.
• W2783160856 cites W1993771353 @default.
• W2783160856 cites W1998217670 @default.
• W2783160856 cites W2001710332 @default.
• W2783160856 cites W2001775594 @default.
• W2783160856 cites W2002905931 @default.
• W2783160856 cites W2009501393 @default.
• W2783160856 cites W2019280950 @default.
• W2783160856 cites W2029077196 @default.
• W2783160856 cites W2066489069 @default.
• W2783160856 cites W2067090279 @default.
• W2783160856 cites W2078413135 @default.
• W2783160856 cites W2089774344 @default.
• W2783160856 cites W2107346812 @default.
• W2783160856 cites W2122344844 @default.
• W2783160856 cites W2137780217 @default.
• W2783160856 cites W2139672588 @default.
• W2783160856 cites W2141478377 @default.
• W2783160856 cites W2143041251 @default.
• W2783160856 cites W2145032636 @default.
• W2783160856 cites W2154464441 @default.
• W2783160856 cites W2162186379 @default.
• W2783160856 cites W2260507520 @default.
• W2783160856 cites W2266921405 @default.
• W2783160856 cites W2317185835 @default.
• W2783160856 cites W2331182968 @default.
• W2783160856 cites W2346364780 @default.
• W2783160856 cites W2395130485 @default.
• W2783160856 cites W2555594290 @default.
• W2783160856 cites W256420945 @default.
• W2783160856 doi "https://doi.org/10.1681/asn.2017060679" @default.
• W2783160856 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5827599" @default.
• W2783160856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29321143" @default.
• W2783160856 hasPublicationYear "2018" @default.
• W2783160856 type Work @default.
• W2783160856 sameAs 2783160856 @default.
• W2783160856 citedByCount "73" @default.
• W2783160856 countsByYear W27831608562018 @default.
• W2783160856 countsByYear W27831608562019 @default.
• W2783160856 countsByYear W27831608562020 @default.
• W2783160856 countsByYear W27831608562021 @default.
• W2783160856 countsByYear W27831608562022 @default.
• W2783160856 countsByYear W27831608562023 @default.
• W2783160856 crossrefType "journal-article" @default.
• W2783160856 hasAuthorship W2783160856A5000254733 @default.
• W2783160856 hasAuthorship W2783160856A5012996331 @default.
• W2783160856 hasAuthorship W2783160856A5024389042 @default.
• W2783160856 hasAuthorship W2783160856A5031884367 @default.
• W2783160856 hasAuthorship W2783160856A5032721048 @default.
• W2783160856 hasAuthorship W2783160856A5035690548 @default.
• W2783160856 hasAuthorship W2783160856A5047785825 @default.
• W2783160856 hasAuthorship W2783160856A5051102653 @default.
• W2783160856 hasAuthorship W2783160856A5056227490 @default.
• W2783160856 hasAuthorship W2783160856A5072931338 @default.
• W2783160856 hasBestOaLocation W27831608561 @default.
• W2783160856 hasConcept C126322002 @default.
• W2783160856 hasConcept C159654299 @default.
• W2783160856 hasConcept C203014093 @default.
• W2783160856 hasConcept C2776090121 @default.
• W2783160856 hasConcept C2778453870 @default.
• W2783160856 hasConcept C2779605438 @default.
• W2783160856 hasConcept C2780303639 @default.
• W2783160856 hasConcept C2780653079 @default.
• W2783160856 hasConcept C2780743877 @default.
• W2783160856 hasConcept C2781101188 @default.
• W2783160856 hasConcept C2911091166 @default.
• W2783160856 hasConcept C2994498544 @default.
• W2783160856 hasConcept C502942594 @default.
• W2783160856 hasConcept C71924100 @default.
• W2783160856 hasConcept C86803240 @default.
• W2783160856 hasConcept C8891405 @default.
• W2783160856 hasConceptScore W2783160856C126322002 @default.
• W2783160856 hasConceptScore W2783160856C159654299 @default.

• next