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• W2783161486 abstract "RIG-I (retinoic acid inducible gene-I) is a cytosolic innate immune protein that senses viral dsRNA with a 5′-triphosphate overhang. Upon interaction with dsRNA a de-repression of the RIG-I CARD domains takes place that ultimately leads to the production of type I interferons and pro-inflammatory cytokines. Here we investigate the RIG-I conformational rearrangement upon interaction with an activating 5′-triphosphate-10-base pair dsRNA hairpin loop (10bp) compared with a less active 5′-triphosphate-8-base pair dsRNA hairpin loop (8bp). We use size-exclusion chromatography–coupled small-angle X-ray scattering (SAXS) and limited tryptic digest experiments to show that that upon binding to 10 bp, but not 8 bp, RIG-I becomes extended and shows greater flexibility, reflecting the release of its CARDs. We also examined the effect of different ATP analogues on the conformational changes of RIG-I/dsRNA complexes. Of the analogues tested, the addition of ATP transition state analogue ADP-AlFx further assisted in the complete activation of RIG-I in complex with 10bp and also to some extent RIG-I bound to 8bp. Together these data provide solution-based evidence for the molecular mechanism of innate immune signaling by RIG-I as stimulated by short hairpin RNA and ATP." @default.
• W2783161486 created "2018-01-26" @default.
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• W2783161486 date "2018-01-13" @default.
• W2783161486 modified "2023-09-27" @default.
• W2783161486 title "Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis" @default.
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• W2783161486 doi "https://doi.org/10.1093/nar/gkx1307" @default.
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• W2783161486 hasPublicationYear "2018" @default.
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