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- W2783162131 abstract "Abstract During the Hsp90-mediated chaperoning of protein kinases, the core components of the machinery, Hsp90 and the cochaperone Cdc37, recycle between different phosphorylation states that regulate progression of the chaperone cycle. We show that Cdc37 phosphorylation at Y298 results in partial unfolding of the C-terminal domain and the population of folding intermediates. Unfolding facilitates Hsp90 phosphorylation at Y197 by unmasking a phosphopeptide sequence, which serves as a docking site to recruit non-receptor tyrosine kinases to the chaperone complex via their SH2 domains. In turn, Hsp90 phosphorylation at Y197 specifically regulates its interaction with Cdc37 and thus affects the chaperoning of only protein kinase clients. In summary, we find that by providing client class specificity, Hsp90 cochaperones such as Cdc37 do not merely assist in client recruitment but also shape the post-translational modification landscape of Hsp90 in a client class-specific manner." @default.
- W2783162131 created "2018-01-26" @default.
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- W2783162131 date "2018-01-17" @default.
- W2783162131 modified "2023-09-25" @default.
- W2783162131 title "Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation" @default.
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- W2783162131 doi "https://doi.org/10.1038/s41467-017-02711-w" @default.
- W2783162131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5772613" @default.
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