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• W2783162844 endingPage "204173141775276" @default.
• W2783162844 startingPage "204173141775276" @default.
• W2783162844 abstract "Dental pulp represents a promising and easily accessible source of mesenchymal stem cells for clinical applications. Many studies have investigated the use of human dental pulp stem cells and stem cells isolated from the dental pulp of human exfoliated deciduous teeth for bone tissue engineering in vivo. However, the type of scaffold used to support the proliferation and differentiation of dental stem cells, the animal model, the type of bone defect created, and the methods for evaluation of results were extremely heterogeneous among these studies conducted. With this issue in mind, the main objective of this study is to present and summarize, through a systematic review of the literature, in vivo studies in which the efficacy of human dental pulp stem cells and stem cells from human exfoliated deciduous teeth (SHED) for bone regeneration was evaluated. The article search was conducted in PubMed/MEDLINE and Web of Science databases. Original research articles assessing potential of human dental pulp stem cells and SHED for in vivo bone tissue engineering, published from 1984 to November 2017, were selected and evaluated in this review according to the following eligibility criteria: published in English, assessing dental stem cells of human origin and evaluating in vivo bone tissue formation in animal models or in humans. From the initial 1576 potentially relevant articles identified, 128 were excluded due to the fact that they were duplicates and 1392 were considered ineligible as they did not meet the inclusion criteria. As a result, 56 articles remained and were fully analyzed in this systematic review. The results obtained in this systematic review open new avenues to perform bone tissue engineering for patients with bone defects and emphasize the importance of using human dental pulp stem cells and SHED to repair actual bone defects in an appropriate animal model." @default.
• W2783162844 created "2018-01-26" @default.
• W2783162844 creator A5002925597 @default.
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• W2783162844 creator A5045379541 @default.
• W2783162844 creator A5068669407 @default.
• W2783162844 date "2018-01-01" @default.
• W2783162844 modified "2023-10-16" @default.
• W2783162844 title "The use of human dental pulp stem cells for in vivo bone tissue engineering: A systematic review" @default.
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• W2783162844 doi "https://doi.org/10.1177/2041731417752766" @default.
• W2783162844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5777558" @default.
• W2783162844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375756" @default.
• W2783162844 hasPublicationYear "2018" @default.
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• W2783162844 citedByCount "82" @default.

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