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- W2783165029 endingPage "760" @default.
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- W2783165029 abstract "Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions. Human neuronal cell model systems have been dramatically developed in recent years with the use of stem cell technology, and these systems may be key tools for overcoming this dilemma and improving our understanding of the dynamic changes in the mitochondrial deficits in patients with psychiatric disorders. We introduce recent discoveries from new experimental models and conclude the discussion by referring to future perspectives. We emphasize the significance of combining studies of human neuronal cell models with those of other experimental systems, including animal models." @default.
- W2783165029 created "2018-01-26" @default.
- W2783165029 creator A5001838062 @default.
- W2783165029 creator A5012840387 @default.
- W2783165029 creator A5033272729 @default.
- W2783165029 creator A5069018183 @default.
- W2783165029 creator A5073964522 @default.
- W2783165029 date "2018-05-01" @default.
- W2783165029 modified "2023-10-12" @default.
- W2783165029 title "Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models" @default.
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