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- W2783169580 abstract "The aim of present work is to prepare floating tablets of famiotidne Hydrochlorideusing HPMC K4M, HPMC K15M and HPMC K100M as polymer. Floating drugdelivery system have a bulk density less than gastric fluids and so remains buoyant in thestomach without affecting gastric emptying rate for a prolonged period of time.Famotidine an a histamine H2 receptor antagonist and used in the treatment of pepticulcer disease (PUD) and gastroesophageal reflux disease (GERD). The short half life offamotidine, shorter resident in stomach and multiple administration dose makefamotidine a very good candidate for formulation of floating drug delivery system.Floating tablets of famotidine were prepared by melt granulation method using HPMCK4M, HPMC K15M and HPMC K100M. The floating tablets was evaluated such asweight variation, hardness, friability, thickness, drug content, , invitro buoyancy, drugpolymer compatibility (IR study ), and invitro dissolution studies of tablets. Themicromeritic properties was found to be good, invitro buoyancy and invitro dissolutionstudies confirmed their good release nature. Formulation F4 prepared with of HPMCK100M shows a good invitro buoyancy lag time & floating time and invitro dissolutionstudies shows a 96.78% release for a period of 12 hrs. The data obtained in this studythus suggest that a floating tablets of famotidine are promising for sustained drugdelivery which can reduce dosing frequency." @default.
- W2783169580 created "2018-01-26" @default.
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- W2783169580 date "2017-10-01" @default.
- W2783169580 modified "2023-09-26" @default.
- W2783169580 title "Formulation Development and Invitro Evaluation of Famotidine Gastroretentive Tablets by Melt Granulation Technique" @default.
- W2783169580 hasPublicationYear "2017" @default.
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