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- W2783171284 abstract "Five novel sulfonamides derivatives HR5-HR8 and HR14 were synthesized by sulfonylation of primary or secondary amine in the presence of base through nucleophilic substitution reaction. Structural elucidation was carried out through FT-IR, UV, 1H NMR, MS and elemental analysis. Prepared compounds were evaluated against pathogenic strains of bacteria (S. aureus and E. coli) and fungi (A. flavous and A. nyger). Results were compared against standard antifungal and bacterial drug already available in market (isoconazole and sulfmethoxazole). It was found that compound HR14 showed good activity with MIC 1.5 µg/mL and 2.0 µg/mL for S. aurues and E. coli, respectively. While HR5 showed best antifungal activity with zone of inhibition 27.2+0.12 mm (MIC: 5.25 µg/mL) and 18.1+0.12 mm (MIC: 12.5 µg/mL) against A. flavous and A. nyger, respectively. Synthesized compounds were also tested for their in vitro antioxidant activity by using DDPH. Amongst all compounds HR5 was found to have potential activity with 15.60% antioxidant activity at 6 mM concentration. KEY WORDS: Sulfonamide, DPPH, AntiMICrobial activity Bull. Chem. Soc. Ethiop. 2017, 31(3), 491-498.DOI: http://dx.doi.org/10.4314/bcse.v31i3.13" @default.
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- W2783171284 date "2018-01-19" @default.
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- W2783171284 title "Synthesis and characterization of novel sulfonamides derivatives and their antimicrobial, antioxidant and cytotoxicity evaluation" @default.
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- W2783171284 doi "https://doi.org/10.4314/bcse.v31i3.13" @default.
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