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- W2783171768 endingPage "314873" @default.
- W2783171768 startingPage "gutjnl" @default.
- W2783171768 abstract "In order to optimally refine the multiple emerging drug targets for hepatitis B virus (HBV), it is vital to evaluate virological and immunological changes at the site of infection. Traditionally liver biopsy has been the mainstay of HBV disease assessment, but with the emergence of non-invasive markers of liver fibrosis, there has been a move away from tissue sampling. Here we argue that liver biopsy remains an important tool, not only for the clinical assessment of HBV but also for research progress and evaluation of novel agents. The importance of liver sampling has been underscored by recent findings of specialised subsets of tissue-resident immune subsets capable of efficient pathogen surveillance, compartmentalised in the liver and not sampled in the blood. Importantly, the assessment of virological parameters, such as cccDNA quantitation, also requires access to liver tissue. We discuss strategies to maximise information obtained from the site of infection and disease pathology. Fine needle aspirates of the liver may allow longitudinal sampling of the local virus/host landscape. The careful utilisation of liver tissue and aspirates in conjunction with blood will provide critical information in the assessment of new therapeutics for the functional cure of HBV." @default.
- W2783171768 created "2018-01-26" @default.
- W2783171768 creator A5015295914 @default.
- W2783171768 creator A5016099890 @default.
- W2783171768 creator A5060929520 @default.
- W2783171768 creator A5085632483 @default.
- W2783171768 date "2018-01-13" @default.
- W2783171768 modified "2023-10-16" @default.
- W2783171768 title "Liver sampling: a vital window into HBV pathogenesis on the path to functional cure" @default.
- W2783171768 cites W1206347461 @default.
- W2783171768 cites W1524685096 @default.
- W2783171768 cites W1554702195 @default.
- W2783171768 cites W1555699566 @default.
- W2783171768 cites W1582767991 @default.
- W2783171768 cites W1582793430 @default.
- W2783171768 cites W1632859538 @default.
- W2783171768 cites W1719532918 @default.
- W2783171768 cites W1820160132 @default.
- W2783171768 cites W1837132695 @default.
- W2783171768 cites W1918954877 @default.
- W2783171768 cites W1939257496 @default.
- W2783171768 cites W1957522192 @default.
- W2783171768 cites W1971197010 @default.
- W2783171768 cites W1974257643 @default.
- W2783171768 cites W1983251878 @default.
- W2783171768 cites W1983931501 @default.
- W2783171768 cites W1986904544 @default.
- W2783171768 cites W1988062715 @default.
- W2783171768 cites W1992007989 @default.
- W2783171768 cites W2006011870 @default.
- W2783171768 cites W2008643979 @default.
- W2783171768 cites W2015035059 @default.
- W2783171768 cites W2020211914 @default.
- W2783171768 cites W2024552072 @default.
- W2783171768 cites W2025561586 @default.
- W2783171768 cites W2026179924 @default.
- W2783171768 cites W2029180341 @default.
- W2783171768 cites W2031317669 @default.
- W2783171768 cites W2035424287 @default.
- W2783171768 cites W2037301794 @default.
- W2783171768 cites W2045046565 @default.
- W2783171768 cites W2048859361 @default.
- W2783171768 cites W2052217197 @default.
- W2783171768 cites W2064823659 @default.
- W2783171768 cites W2065426843 @default.
- W2783171768 cites W2074118280 @default.
- W2783171768 cites W2077533125 @default.
- W2783171768 cites W2080604053 @default.
- W2783171768 cites W2081536518 @default.
- W2783171768 cites W2082595913 @default.
- W2783171768 cites W2084857559 @default.
- W2783171768 cites W2089247679 @default.
- W2783171768 cites W2096782011 @default.
- W2783171768 cites W2099184552 @default.
- W2783171768 cites W2099665776 @default.
- W2783171768 cites W2100856307 @default.
- W2783171768 cites W2103338170 @default.
- W2783171768 cites W2106374963 @default.
- W2783171768 cites W2106908798 @default.
- W2783171768 cites W2110217973 @default.
- W2783171768 cites W2113077209 @default.
- W2783171768 cites W2116118057 @default.
- W2783171768 cites W2117407070 @default.
- W2783171768 cites W2119954580 @default.
- W2783171768 cites W2121514783 @default.
- W2783171768 cites W2132205831 @default.
- W2783171768 cites W2132849527 @default.
- W2783171768 cites W2137327945 @default.
- W2783171768 cites W2140430530 @default.
- W2783171768 cites W2144808865 @default.
- W2783171768 cites W2148300725 @default.
- W2783171768 cites W2152095262 @default.
- W2783171768 cites W2152659372 @default.
- W2783171768 cites W2156015715 @default.
- W2783171768 cites W2156330680 @default.
- W2783171768 cites W2158039903 @default.
- W2783171768 cites W2159616534 @default.
- W2783171768 cites W2166333477 @default.
- W2783171768 cites W2169967366 @default.
- W2783171768 cites W2172292919 @default.
- W2783171768 cites W2173698250 @default.
- W2783171768 cites W2273021913 @default.
- W2783171768 cites W2278161602 @default.
- W2783171768 cites W2293727898 @default.
- W2783171768 cites W2338215546 @default.
- W2783171768 cites W2340384276 @default.
- W2783171768 cites W2345009038 @default.
- W2783171768 cites W2346928357 @default.
- W2783171768 cites W2407297694 @default.
- W2783171768 cites W2407488932 @default.
- W2783171768 cites W2408333651 @default.
- W2783171768 cites W2408392972 @default.
- W2783171768 cites W2462340700 @default.
- W2783171768 cites W2464020216 @default.
- W2783171768 cites W2488342729 @default.
- W2783171768 cites W2494120090 @default.
- W2783171768 cites W2496750792 @default.
- W2783171768 cites W2513850233 @default.