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• W2783172145 endingPage "129" @default.
• W2783172145 startingPage "114" @default.
• W2783172145 abstract "Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic acid bases inside the base-stack, base analogue donor and acceptor molecules complement external fluorophores like the Cy-, Alexa- and ATTO-dyes and enable detailed investigations of structure and dynamics of nucleic acid containing systems. The first base-base FRET pair, tCO-tCnitro, has recently been complemented with among others the adenine analogue FRET pair, qAN1-qAnitro, increasing the flexibility of the methodology. Here we present the design, synthesis, photophysical characterization and use of such base analogues. They enable a higher control of the FRET orientation factor, κ2, have a different distance window of opportunity than external fluorophores, and, thus, have the potential to facilitate better structure resolution. Netropsin DNA binding and the B-to-Z-DNA transition are examples of structure investigations that recently have been performed using base-base FRET and that are described here. Base-base FRET has been around for less than a decade, only in 2017 expanded beyond one FRET pair, and represents a highly promising structure and dynamics methodology for the field of nucleic acids. Here we bring up its advantages as well as disadvantages and touch upon potential future applications." @default.
• W2783172145 created "2018-01-26" @default.
• W2783172145 creator A5024573440 @default.
• W2783172145 creator A5053244201 @default.
• W2783172145 creator A5061533495 @default.
• W2783172145 creator A5091271050 @default.
• W2783172145 creator A5091395541 @default.
• W2783172145 date "2018-01-10" @default.
• W2783172145 modified "2023-10-14" @default.
• W2783172145 title "Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications" @default.
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• W2783172145 doi "https://doi.org/10.3762/bjoc.14.7" @default.
• W2783172145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5789401" @default.
• W2783172145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29441135" @default.
• W2783172145 hasPublicationYear "2018" @default.
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