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- W2783174768 abstract "There are very few reports which suggest an association between clozapine and hypertension. We report a case in which a direct link of initiation of clozapine to development of hypertension which required pharmacological intervention. A 32-year-old male who did not have any history of hypertension and had normal blood pressure at the baseline developed high blood pressure (i.e., 150/90 mmHg) while on clozapine 100 mg/day. Reduction of the dose of clozapine to 75 mg/day led to the return of blood pressure to baseline, with increase in blood pressure to 150/90 mmHg on increasing the dose of clozapine again, requiring tablet atenolol 50 mg/day for normalization of blood pressure with concomitant continuation of atenolol. Later, clozapine was increased to 350 mg/day, with no recurrence of raise in blood pressure. After 6 months, tablet atenolol was stopped with no evidence of hypertension in follow-up. To conclude, this case report suggests that clozapine can rarely lead to hypertension during the initial phase of treatment." @default.
- W2783174768 created "2018-01-26" @default.
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- W2783174768 date "2017-01-01" @default.
- W2783174768 modified "2023-09-27" @default.
- W2783174768 title "Clozapine-induced hypertension: A case report and review of literature" @default.
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- W2783174768 doi "https://doi.org/10.4103/ipj.ipj_9_16" @default.
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