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- W2783174968 abstract "The synthesis of multifunctional spirocycles was achieved from common cyclic carboxylic acids (cyclobutane carboxylate, cyclopentane carboxylate, l-proline, etc.). The whole sequence included only two chemical steps-synthesis of azetidinones, and reduction into azetidines. The obtained spirocyclic amino acids were incorporated into a structure of the known anesthetic drug Bupivacaine. The obtained analogues were more active and less toxic than the original drug. We believe that this discovery will lead to a wide use of spirocyclic building blocks in drug discovery in the near future." @default.
- W2783174968 created "2018-01-26" @default.
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- W2783174968 date "2018-02-15" @default.
- W2783174968 modified "2023-10-03" @default.
- W2783174968 title "Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery" @default.
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- W2783174968 doi "https://doi.org/10.1002/chem.201800193" @default.
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